Dnmt3a silences hematopoietic stem cell self-renewal.

Authors

Jennifer J. Trowbridge, The Jackson LaboratoryFollow
Stuart H Orkin

Document Type

Article

Publication Date

1-2012

Keywords

Cell Differentiation, Cell Division, DNA (Cytosine-5-)-Methyltransferase, DNA Methylation, Hematopoietic Stem Cells, RNA Interference

JAX Source

Nat Genet 2012 Jan; 44(1):13-4.

PMID

22200773

Volume

44

Issue

1

First Page

13

Last Page

14

ISSN

1546-1718

Abstract

DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.

Recommended Citation

Trowbridge JJ, Orkin S. Dnmt3a silences hematopoietic stem cell self-renewal. Nat Genet 2012 Jan; 44(1):13-4.