Dnmt3a silences hematopoietic stem cell self-renewal.
Cell Differentiation, Cell Division, DNA (Cytosine-5-)-Methyltransferase, DNA Methylation, Hematopoietic Stem Cells, RNA Interference
Nat Genet 2012 Jan; 44(1):13-4.
DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.
Trowbridge, Jennifer J. and Orkin, Stuart H, "Dnmt3a silences hematopoietic stem cell self-renewal." (2012). Faculty Research 2012. 225.