Title

Dnmt3a silences hematopoietic stem cell self-renewal.

Document Type

Article

Publication Date

1-2012

Keywords

Cell Differentiation, Cell Division, DNA (Cytosine-5-)-Methyltransferase, DNA Methylation, Hematopoietic Stem Cells, RNA Interference

JAX Source

Nat Genet 2012 Jan; 44(1):13-4.

PMID

22200773

Abstract

DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.