Title

Signals for pre-mRNA cleavage and polyadenylation.

Document Type

Article

Publication Date

5-2012

Keywords

Animals, Computational Biology, Humans, Plants, Poly A, Polyadenylation, Polynucleotide Adenylyltransferase, RNA Precursors, Regulatory Sequences, Nucleic Acid, Saccharomyces cerevisiae, mRNA Cleavage and Polyadenylation Factors

JAX Location

Reprint Collection

JAX Source

Wiley Interdiscip Rev RNA 2012 May-Jun; 3(3):385-96.

PMID

22012871

Abstract

Pre-mRNA cleavage and polyadenylation is an essential step for 3' end formation of almost all protein-coding transcripts in eukaryotes. The reaction, involving cleavage of nascent mRNA followed by addition of a polyadenylate or poly(A) tail, is controlled by cis-acting elements in the pre-mRNA surrounding the cleavage site. Experimental and bioinformatic studies in the past three decades have elucidated conserved and divergent elements across eukaryotes, from yeast to human. Here we review histories and current models of these elements in a broad range of species.

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