Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines.
Document Type
Article
Publication Date
4-18-2013
Keywords
Adaptive Immunity, Antibody Formation, Cell Proliferation, Humans, Immunity, Innate, Inflammation Mediators, Influenza Vaccines, Influenza, Human, Interferons, Myeloid Cells, Neutrophils, Orthomyxoviridae, Pneumococcal Infections, Pneumococcal Vaccines, Software, Streptococcus pneumoniae, Vaccination
JAX Source
Immunity 2013 Apr 18; 38(4):831-44.
Volume
38
Issue
4
First Page
831
Last Page
844
ISSN
1097-4180
PMID
23601689
Abstract
Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination. Immunity 2013 Apr 18; 38(4):831-44.
Recommended Citation
Obermoser G,
Presnell S,
Domico K,
Xu H,
Wang Y,
Anguiano E,
Thompson-Snipes L,
Ranganathan R,
Zeitner B,
Bjork A,
Anderson D,
Speake C,
Ruchaud E,
Skinner J,
Alsina L,
Sharma M,
Dutartre H,
Cepika A,
Israelsson E,
Nguyen P,
Nguyen Q,
Harrod A,
Zurawski S,
Pascual V,
Ueno H,
Nepom G,
Quinn C,
Blankenship D,
Palucka K,
Banchereau J,
Chaussabel D.
Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines. Immunity 2013 Apr 18; 38(4):831-44.