Title

Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene.

Document Type

Article

Publication Date

2013

Keywords

Animals, Asthma, Base Sequence, Female, Genome-Wide Association Study, Genotype, Humans, Kv Channel-Interacting Proteins, Male, Mice, Phenotype, Polymorphism, Single Nucleotide

JAX Source

PLoS One 2013; 8(2):e56179.

PMID

23457522

Abstract

Asthma is a common chronic respiratory disease characterized by airway hyperresponsiveness (AHR). The genetics of asthma have been widely studied in mouse and human, and homologous genomic regions have been associated with mouse AHR and human asthma-related phenotypes. Our goal was to identify asthma-related genes by integrating AHR associations in mouse with human genome-wide association study (GWAS) data. We used Efficient Mixed Model Association (EMMA) analysis to conduct a GWAS of baseline AHR measures from males and females of 31 mouse strains. Genes near or containing SNPs with EMMA p-values. PLoS One 2013; 8(2):e56179.