Title

Mouse models for studies of retinal degeneration and diseases.

Document Type

Article

Publication Date

2013

Keywords

Animals, Disease Models, Animal, Electroretinography, Fluorescein Angiography, Fundus Oculi, Genetic Testing, Humans, Mice, Ophthalmoscopy, Retina, Retinal Degeneration

JAX Location

Reprint Collection

JAX Source

Methods Mol Biol 2013; 935:27-39.

PMID

23150358

Abstract

Mouse models, with their well-developed genetics and similarity to human physiology and anatomy, serve as powerful tools with which to investigate the etiology of human retinal degeneration. Mutant mice also provide reproducible, experimental systems for elucidating pathways of normal development and function. Here, I describe the tools used in the discoveries of many retinal degeneration models, including indirect ophthalmoscopy (to look at the fundus appearance), fundus photography and fluorescein angiography (to document the fundus appearance), electroretinography (to check retinal function), as well as the heritability test (for genetic characterization). Methods Mol Biol 2013; 935:27-39.

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