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Submissions from 2014

Clinical trial evidence of the antitumor activity of topical imiquimod for breast cancer skin metastases., Sylvia Adams, Yelena Novik, Ruth Oratz, Deborah Axelrod, James Speyer, Amy Tiersten, Judith D Goldberg, Nina Bhardwaj, Derya Unutmaz, Sandra Demaria, and Silvia Formenti

Genomic portrait of resectable hepatocellular carcinomas: Implications of RB1 and FGF19 aberrations for patient stratification., Sung-Min Ahn, Se Jin Jang, Ju Hyun Shim, Deokhoon Kim, Seung-Mo Hong, Chang Ohk Sung, Daehyun Baek, Farhan Haq, Adnan Ahmad Ansari, Sun Young Lee, Sung-Min Chun, Seongmin Choi, Hyun-Jeung Choi, Jongkyu Kim, Sukjun Kim, Shin Hwang, Young-Joo Lee, Jong-Eun Lee, Wang-Rim Jung, Hye Yoon Jang, Eunho Yang, Wing-Kin Sung, Nikki P Lee, Mao Mao, Charles Lee, Jessica Zucman-Rossi, Eunsil Yu, Han Chu Lee, and Gu Kong

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Representing kidney development using the gene ontology., Yasmin Alam-Faruque, David P. Hill, Emily C Dimmer, Midori A Harris, Rebecca E Foulger, Susan Tweedie, Helen Attrill, Douglas G Howe, Stephen Randall Thomas, Duncan Davidson, Adrian S Woolf, Judith A. Blake, Christopher J Mungall, Claire O'Donovan, Rolf Apweiler, and Rachael P Huntley

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Whole-Genome Sequence of the C57L/J Mouse Inbred Strain., Guruprasad Ananda, Yuka Takemon, Douglas Hinerfeld, and Ron Korstanje

Antiepileptic activity of preferential inhibitors of persistent sodium current., Lyndsey L Anderson, Christopher H Thompson, Nicole A Hawkins, Ravi D Nath, Adam A Petersohn, Sridharan Rajamani, William S Bush, Wayne N. Frankel, Carlos G Vanoye, Jennifer A Kearney, and Alfred L George

Immunodeficient mouse model for human hematopoietic stem cell engraftment and immune system development., Ken-Edwin Aryee, Leonard D. Shultz, and Michael A Brehm

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Methodology for the inference of gene function from phenotype data., Joao A. Ascensao, Mary E. Dolan, David P. Hill, and Judith A. Blake

Familial Alström syndrome: a rare cause of bilateral progressive hearing loss., Fayez Bahmad Jr, Carolina Sousa Alves Costa, Marina Santos Teixeira, Jairo de Barros Filho, Lucas Moura Viana, and Jan D. Marshall

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PRDM9 binding organizes hotspot nucleosomes and limits Holliday junction migration., Christopher L. Baker, Michael Walker, Shimpei Kajita, Petko M. Petkov, and Kenneth Paigen

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Identifying common components across biological network graphs using a bipartite data model., Ej Baker, C Culpepper, C Philips, Jason A. Bubier, M Langston, and Elissa J. Chesler

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Transcriptional specialization of human dendritic cell subsets in response to microbial vaccines., Romain Banchereau, Nicole Baldwin, Alma-Martina Cepika, Shruti Athale, Yaming Xue, Chun I Yu, Patrick Metang, Abhilasha Cheruku, Isabelle Berthier, Ingrid Gayet, Yuanyuan Wang, Marina Ohouo, LuAnn Snipes, Hui Xu, Gerlinde Obermoser, Derek Blankenship, Sangkon Oh, Octavio Ramilo, Damien Chaussabel, Jacques Banchereau, Karolina Palucka, and Virginia Pascual

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Engraftment of human primary acute myeloid leukemia defined by integrated genetic profiling in NOD/SCID/IL2rynull mice for preclinical ceramide-based therapeutic evaluation., Brian M. Barth, Nichole R. Keasey, Xujung Wang, Sriram S. Shanmugavelandy, Raajit Rampal, Todd Hricik, Myles C. Cabot, Mark Kester, Hong-Gang Wang, Leonard D. Shultz, Martin S. Tallman, Ross L. Levine, Thomas P. Loughran Jr, and David F. Claxton

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Identifying mouse models for skin cancer using the Mouse Tumor Biology Database., Dale A. Begley, Debra M. Krupke, Steven Neuhauser, Joel E Richardson, Paul N Schofield, Carol J. Bult, Janan T. Eppig, and John P. Sundberg

The relationships between environmental bacterial exposure, airway bacterial colonization, and asthma., Avraham Beigelman, George M. Weinstock, and Leonard B Bacharier

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H3K4me3 Breadth Is Linked to Cell Identity and Transcriptional Consistency., Bérénice A Benayoun, Elizabeth A Pollina, Duygu Ucar, Salah Mahmoudi, Kalpana Karra, Edith D Wong, Keerthana Devarajan, Aaron C Daugherty, Anshul B Kundaje, Elena Mancini, Benjamin C Hitz, Rakhi Gupta, Thomas A Rando, Julie C Baker, Michael P Snyder, J Michael Cherry, and Anne Brunet

Phenotypic Characterization of the KK/HlJ Inbred Mouse Strain., A Berndt, Beth A. Sundberg, Kathleen A. Silva, Victoria E. Kennedy, M A Richardson, Q Li, R T Bronson, J Uitto, and John P. Sundberg

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Insulin-like growth factor-1 stimulates regulatory T cells and suppresses autoimmune disease., Daniel Bilbao, Luisa Luciani, Bjarki Johannesson, Agnieszka Piszczek, and Nadia Rosenthal

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Clonal Evolution Enhances Leukemia-Propagating Cell Frequency in T Cell Acute Lymphoblastic Leukemia through Akt/mTORC1 Pathway Activation., Jessica S Blackburn, Sali Liu, Jayme L Wilder, Kimberly P Dobrinski, Riadh Lobbardi, Finola E Moore, Sarah A Martinez, Eleanor Y Chen, Charles Lee, and David M Langenau

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The Mouse Genome Database: integration of and access to knowledge about the laboratory mouse., Judith A. Blake, Carol J. Bult, Janan T. Eppig, James A. Kadin, Joel E Richardson, and Mouse Genome Database Group

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Identification of the Key Differential Transcriptional Responses of Human Whole Blood Following TLR2 or TLR4 Ligation In-Vitro., Simon Blankley, Christine M Graham, Ashleigh Howes, Chloe I Bloom, Matthew P R Berry, Damien Chaussabel, Virginia Pascual, Jacques Banchereau, Marc Lipman, and Anne O'Garra

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Cryptic and complex chromosomal aberrations in early-onset neuropsychiatric disorders., Harrison Brand, Vamsee Pillalamarri, Ryan L Collins, Stacey Eggert, Colm O'Dushlaine, Ellen B Braaten, Matthew R Stone, Kimberly Chambert, Nathan D Doty, Carrie Hanscom, Jill A Rosenfeld, Hillary Ditmars, Jessica Blais, Ryan Mills, Charles Lee, James F Gusella, Steven McCarroll, Jordan W Smoller, Michael E Talkowski, and Alysa E Doyle

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Generation of improved humanized mouse models for human infectious diseases., Michael A Brehm, Michael V. Wiles, Dale L Greiner, and Leonard D. Shultz

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Identification of a QTL in Mus musculus for Alcohol Preference, Withdrawal, and Ap3m2 Expression Using Integrative Functional Genomics and Precision Genetics., Jason A. Bubier, Jeremy Jay, Christopher L. Baker, Susan E Bergeson, Hiroshi Ohno, Pamela Metten, John C Crabbe, and Elissa J. Chesler

Impaired hypercarbic and hypoxic responses from developmental loss of cerebellar purkinje neurons: implications for sudden infant death syndrome., M Calton, Price E. Dickson, R M Harper, D Goldowitz, and G Mittleman

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A lack of immune system genes causes loss in high frequency hearing but does not disrupt cochlear synapse maturation in mice., Melissa A Calton, Dasom Lee, Srividya Sundaresan, Diana Mendus, Rose Leu, Felix Wangsawihardja, Kenneth R. Johnson, and Mirna Mustapha

Differences in antibody responses between trivalent inactivated influenza vaccine and live attenuated influenza vaccine correlate with the kinetics and magnitude of interferon signaling in children., Raquel G Cao, Nicolas M Suarez, Gerlinde Obermoser, Santiago M C Lopez, Emilio Flano, Sara E Mertz, Randy A Albrecht, Adolfo García-Sastre, Asuncion Mejias, Hui Xu, Huanying Qin, Derek Blankenship, Karolina Palucka, Virginia Pascual, and Octavio Ramilo

Sepsis from the gut: the enteric habitat of bacteria that cause late-onset neonatal bloodstream infections., Mike A Carl, I Malick Ndao, A Cody Springman, Shannon D Manning, James R Johnson, Brian D Johnston, Carey-Ann D Burnham, Erica Sodergren Weinstock, George M. Weinstock, Todd N Wylie, Makedonka Mitreva, Sahar Abubucker, Yanjiao Zhou, Harold J Stevens, Carla Hall-Moore, Samuel Julian, Nurmohammad Shaikh, Barbara B Warner, and Phillip I Tarr

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Androgen-dependent sertoli cell tight junction remodeling is mediated by multiple tight junction components., Papia Chakraborty, F William Buaas, Manju Sharma, Benjamin E Smith, Anne R Greenlee, Stephen M Eacker, and Robert E. Braun

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LIN28A Marks the Spermatogonial Progenitor Population and Regulates Its Cyclic Expansion., Papia Chakraborty, F William Buaas, Manju Sharma, Elizabeth Snyder, Dirk G de Rooij, and Robert E. Braun

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Dissecting the chromatin interactome of microRNA genes., Dijun Chen, Liang-Yu Fu, Zhao Zhang, Guoliang Li, Hang Zhang, Li Jiang, Andrew P Harrison, Hugh P Shanahan, Christian Klukas, Hong-Yu Zhang, Yijun Ruan, Ling-Ling Chen, and Ming Chen

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Out of the bottleneck: the Diversity Outcross and Collaborative Cross mouse populations in behavioral genetics research., Elissa J. Chesler

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Standardized description of scientific evidence using the Evidence Ontology (ECO)., Marcus C Chibucos, Christopher J Mungall, Rama Balakrishnan, Karen R. Christie, Rachael P Huntley, Owen White, Judith A. Blake, Suzanna E Lewis, and Michelle Giglio

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Epigenetic States of cells of origin and tumor evolution drive tumor-initiating cell phenotype and tumor heterogeneity., Kin-Hoe Chow, Dong-Mi Shin, Molly H Jenkins, Emily E Miller, David J Shih, Seungbum Choi, Benjamin E. Low, Vivek M. Philip, Brad Rybinski, Roderick T Bronson, Michael D Taylor, and Kyuson Yun

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Germline Quality Control: eEF2K Stands Guard to Eliminate Defective Oocytes., Hsueh-Ping Chu, Yi Liao, James S Novak, Zhixian Hu, Jason J Merkin, Yuriy Shymkiv, Bart P Braeckman, Maxim V Dorovkov, Alexandra Nguyen, Peter M Clifford, Robert G Nagele, David E. Harrison, Ronald E Ellis, and Alexey G Ryazanov

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Iron Regulatory Protein-1 Protects against Mitoferrin-1-deficient Porphyria., Jacky Chung, Sheila A Anderson, Babette Gwynn, Kathryn M Deck, Michael J Chen, Nathaniel B Langer, George C Shaw, Nicholas C Huston, Leah F Boyer, Sumon Datta, Prasad N Paradkar, Liangtao Li, Zong Wei, Amy J Lambert, Kenneth Sahr, Johannes G Wittig, Wen Chen, Wange Lu, Bruno Galy, Thorsten M Schlaeger, Matthias W Hentze, Diane M Ward, Jerry Kaplan, Richard S Eisenstein, Luanne L. Peters, and Barry H Paw

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Misleading results: don't blame the mice., Gary A. Churchill

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When are results too good to be true?, Gary A. Churchill

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3-Dimensional histological reconstruction and imaging of the murine pancreas., Steven L. Ciciotte, Mark Lessard, Ellen C. Akeson, Elizabeth Cameron, Timothy M. Stearns, James M. Denegre, Jesus Ruberte, and Karen L. Svenson

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Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival., Jonathan A Coleman, Xianjun Zhu, Hidayat R Djajadi, Laurie L Molday, Richard Smith, Richard T Libby, Simon W M John, and Robert S Molday

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A promoter-level mammalian expression atlas., FANTOM Consortium and Judith A. Blake

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A Dominant-Negative Mutation of Mouse Lmx1b Causes Glaucoma and Is Semi-lethal via LBD1-Mediated Dimerisation., Sally H Cross, Danilo G Macalinao, Lisa McKie, Lorraine Rose, Alison L Kearney, Joe Rainger, Caroline Thaung, Margaret Keighren, Shalini Jadeja, Katrine West, Stephen C. Kneeland, Richard S. Smith, Gareth R. Howell, Fiona Young, Morag Robertson, Rob van T' Hof, Simon WM John, and Ian J Jackson

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Derivation and characterization of mouse embryonic stem cells from permissive and nonpermissive strains., Anne Czechanski, Candice Byers, Ian Greenstein, Nadine Schrode, Leah Rae Donahue, Anna-Katerina Hadjantonakis, and Laura G Reinholdt

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Transplantable Malignant Melanoma in LT.B6 Congenic Mice Resembling Pigmented Epithelioid Melanocytoma in Humans., Soheil S Dadras, Kathleen A. Silva, Lloyd E King, and John P. Sundberg

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AAV-mediated lysophosphatidylcholine acyltransferase 1 (Lpcat1) gene replacement therapy rescues retinal degeneration in rd11 mice., Xufeng Dai, Juanjuan Han, Yan Qi, Hua Zhang, Lue Xiang, Jineng Lv, Jie Li, Wen-Tao Deng, Bo Chang, William W Hauswirth, and Ji-jing Pang

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Genomic Epidemiology of Salmonella enterica Serotype Enteritidis based on Population Structure of Prevalent Lineages., Xiangyu Deng, Prerak T Desai, Henk C den Bakker, Matthew Mikoleit, Beth Tolar, Eija Trees, Rene S Hendriksen, Jonathan G Frye, Steffen Porwollik, Bart C Weimer, Martin Wiedmann, George M. Weinstock, Patricia I Fields, and Michael McClelland

Whole-Genome Analyses of Enterococcus faecium Isolates with Diverse Daptomycin MICs., Lorena Diaz, Truc T Tran, Jose M Munita, William R Miller, Sandra Rincon, Lina P Carvajal, Aye Wollam, Jinnethe Reyes, Diana Panesso, Natalia L Rojas, Yousif Shamoo, Barbara E Murray, George M. Weinstock, and Cesar A Arias

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Performance of C57BL/6J and DBA/2J mice on a touchscreen-based attentional set-shifting task., Price E. Dickson, Michele A Calton, and Guy Mittleman

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Evaluation of cancer immunity in mice., Mary L Disis and Karolina Palucka

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Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse., Tia DiTommaso, Lynelle K Jones, Denny L Cottle, Anna-Karin Gerdin, Valerie E Vancollie, Fiona M Watt, Ramiro Ramirez-Solis, Allan Bradley, Karen P Steel, John P. Sundberg, Jacqueline K White, and Ian M Smyth

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HCoDES Reveals Chromosomal DNA End Structures with Single-Nucleotide Resolution., Yair Dorsett, Yanjiao Zhou, Anthony T Tubbs, Bo-Ruei Chen, Caitlin Purman, Baeck-Seung Lee, Rosmy George, Andrea L Bredemeyer, Jiang-Yang Zhao, Erica Sodergren Weinstock, George M. Weinstock, Nathan D Han, Alejandro Reyes, Eugene M Oltz, Dale Dorsett, Ziva Misulovin, Jacqueline E Payton, and Barry P Sleckman

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Comparison between two labeled agents in mice using a coinjection-ratio approach in contrast to a conventional group approach., Shuping Dou, Yuzhen Wang, Bruce Barton, Ling Chen, Mary Rusckowski, Leonard D. Shultz, Dale L Greiner, and Guozheng Liu

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Novel insights into embryonic stem cell self-renewal revealed through comparative human and mouse systems biology networks., Karen G. Dowell, Allen K. Simons, Hao Bai, Braden Kell, Zack Z Wang, Kyuson Yun, and Matthew A Hibbs

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Genomic Classification of Serous Ovarian Cancer with Adjacent Borderline Differentiates RAS Pathway and TP53-Mutant Tumors and Identifies NRAS as an Oncogenic Driver., Catherine Emmanuel, Yoke-Eng Chiew, Joshy George, Dariush Etemadmoghadam, Michael S Anglesio, Raghwa Sharma, Peter Russell, Catherine Kennedy, Sian Fereday, Jillian Hung, Laura Galletta, Russell Hogg, Gerard V Wain, Alison Brand, Rosemary Balleine, Laura MacConaill, Emanuele Palescandolo, Sally M Hunter, Ian Campbell, Alexander Dobrovic, Stephen Q Wong, Hongdo Do, Christine L Clarke, Paul R Harnett, David D L Bowtell, and Anna deFazio

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Macrophage- and neutrophil-derived TNF-α instructs skin langerhans cells to prime antiviral immune responses., Olivier Epaulard, Lucille Adam, Candice Poux, Gerard Zurawski, Nina Salabert, Pierre Rosenbaum, Nathalie Dereuddre-Bosquet, Sandra Zurawski, Anne-Laure Flamar, Sangkon Oh, Gabrielle Romain, Catherine Chapon, Jacques Banchereau, Yves Lévy, Roger Le Grand, and Frédéric Martinon

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GLUT4 Defects in Adipose Tissue Are Early Signs of Metabolic Alterations in Alms1GT/GT, a Mouse Model for Obesity and Insulin Resistance., Francesca Favaretto, Gabriella Milan, Gayle B. Collin, Jan D. Marshall, Fabio Stasi, Pietro Maffei, Roberto Vettor, and Juergen K. Naggert

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DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury., Kimberly A Fernandes, Jeffrey M Harder, Simon W M John, Peter Shrager, and Richard T Libby

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Unraveling genetic modifiers in the gria4 mouse model of absence epilepsy., Wayne N. Frankel, Connie L. Mahaffey, Tracy C. McGarr, Barbara J. Beyer, and Verity A. Letts

Theory-of-mind in adolescents and young adults with Alström syndrome., Hans Erik Frölander, Claes Möller, Jan D. Marshall, Annette Sundqvist, Berit Rönnåsen, Lil Falkensson, and Björn Lyxell

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Classification of current anticancer immunotherapies., Lorenzo Galluzzi, Erika Vacchelli, José-Manuel Bravo-San Pedro, Aitziber Buqué, Laura Senovilla, Elisa Elena Baracco, Norma Bloy, Francesca Castoldi, Jean-Pierre Abastado, Patrizia Agostinis, Ron N Apte, Fernando Aranda, Maha Ayyoub, Philipp Beckhove, Jean-Yves Blay, Laura Bracci, Anne Caignard, Chiara Castelli, Federica Cavallo, Estaban Celis, Vincenzo Cerundolo, Aled Clayton, Mario P Colombo, Lisa Coussens, Madhav V Dhodapkar, Alexander M Eggermont, Douglas T Fearon, Wolf H Fridman, Jitka Fučíková, Dmitry I Gabrilovich, Jérôme Galon, Abhishek Garg, François Ghiringhelli, Giuseppe Giaccone, Eli Gilboa, Sacha Gnjatic, Axel Hoos, Anne Hosmalin, Dirk Jäger, Pawel Kalinski, Klas Kärre, Oliver Kepp, Rolf Kiessling, John M Kirkwood, Eva Klein, Alexander Knuth, Claire E Lewis, Roland Liblau, Michael T Lotze, Enrico Lugli, Jean-Pierre Mach, Fabrizio Mattei, Domenico Mavilio, Ignacio Melero, Cornelis J Melief, Elizabeth A Mittendorf, Lorenzo Moretta, Adekunke Odunsi, Hideho Okada, Karolina Palucka, Marcus E Peter, Kenneth J Pienta, Angel Porgador, George C Prendergast, Gabriel A Rabinovich, Nicholas P Restifo, Naiyer Rizvi, Catherine Sautès-Fridman, Hans Schreiber, Barbara Seliger, Hiroshi Shiku, Bruno Silva-Santos, Mark J Smyth, Daniel E Speiser, Radek Spisek, Pramod K Srivastava, James E Talmadge, Eric Tartour, Sjoerd H Van Der Burg, Benoît J Van Den Eynde, Richard Vile, Hermann Wagner, Jeffrey S Weber, Theresa L Whiteside, Jedd D Wolchok, Laurence Zitvogel, Weiping Zou, and Guido Kroemer

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In Vivo Detection of Peripherin-Specific Autoreactive B Cells during Type 1 Diabetes Pathogenesis., Nahir Garabatos, Raimon Alvarez, Jorge Carrillo, Jorge Carrascal, Cristina Izquierdo, Harold D. Chapman, Maximiliano Presa, Conchi Mora, David V. Serreze, Joan Verdaguer, and Thomas Stratmann

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Quantitative trait locus mapping methods for diversity outbred mice., Daniel Mario Gatti, Karen L. Svenson, Andrey Shabalin, Long-Yang Wu, William Valdar, Petr Simecek, Neal Goodwin, Riyan Cheng, Daniel Pomp, Abraham Palmer, Elissa J. Chesler, Karl W Broman, and Gary Churchill

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Regulated Splicing of the α6 Integrin Cytoplasmic Domain Determines the Fate of Breast Cancer Stem Cells., Hira Lal Goel, Tatiana Gritsko, Bryan Pursell, Cheng Chang, Leonard D. Shultz, Dale L Greiner, Jens Henrik Norum, Rune Toftgard, Leslie M Shaw, and Arthur M Mercurio

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Alterations in thin filament length during postnatal skeletal muscle development and aging in mice., David S Gokhin, Emily A Dubuc, Kendra Q Lian, Luanne L. Peters, and Velia M Fowler

Brazilian quilombos: A repository of Amerindian alleles., Carolina Carvalho Gontijo, Carlos Eduardo Guerra Amorim, Neide Maria Oliveira Godinho, Rafaela Cesare Parmezan Toledo, Adriana Nunes, Wellington Silva, Maria Manuela Da Fonseca Moura, José Carlos Coutinho De Oliveira, Rubiani C Pagotto, Maria De Nazaré Klautau-Guimarães, and Silviene Fabiana De Oliveira

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Alternative method of oral administration by peanut butter pellet formulation results in target engagement of BACE1 and attenuation of gavage-induced stress responses in mice., C Gonzales, M M Zaleska, D R Riddell, K P Atchison, A Robshaw, H Zhou, and S J Sukoff Rizzo

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Mouse phenome database., Stephen C. Grubb, Carol J. Bult, and Molly A. Bogue

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Functional chromatin features are associated with structural mutations in cancer., Krzysztof R. Grzeda, Beryl Royer-Bertrand, Koichiro Inaki, Hyunsoo Kim, Axel M Hillmer, Edison T. Liu, and Jeffrey Chuang

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Novel neuroprotective GSK-3β inhibitor restricts Tat-mediated HIV-1 replication., Irene Guendel, Sergey Iordanskiy, Rachel Van Duyne, Kylene Kehn-Hall, Mohammed Saifuddin, Ravi Das, Elizabeth Jaworski, Gavin C Sampey, Svetlana Senina, Leonard D. Shultz, Aarthi Narayanan, Hao Chen, Benjamin Lepene, Chen Zeng, and Fatah Kashanchi

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Unification of multi-species vertebrate anatomy ontologies for comparative biology in Uberon., Melissa A Haendel, James P Balhoff, Frederic B Bastian, David C Blackburn, Judith A. Blake, Yvonne Bradford, Aurelie Comte, Wasila M Dahdul, Thomas A Dececchi, Robert E Druzinsky, Terry F. Hayamizu, Nizar Ibrahim, Suzanna E Lewis, Paula M Mabee, Anne Niknejad, Marc Robinson-Rechavi, Paul C Sereno, and Christopher J Mungall

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Applying "gold standards" to in-vitro-derived germ cells., Mary Ann Handel, John J. Eppig, and John C Schimenti

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Genetically diverse mice are novel and valuable models of age-associated susceptibility to Mycobacterium tuberculosis., David E. Harrison, Clinton M. Astle, M Khalid Khan Niazi, Samuel Major, and Gillian L Beamer

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Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males., David E. Harrison, Randy Strong, David B Allison, Bruce N Ames, Clinton M. Astle, Hani Atamna, Elizabeth Fernandez, Kevin Flurkey, Martin A Javors, Nancy L Nadon, James F Nelson, Scott Pletcher, James W Simpkins, Daniel Smith, J Erby Wilkinson, and Richard A Miller

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Characterization of a spontaneous retinal neovascular mouse model., Eiichi Hasegawa, Harry Sweigard, Deeba Husain, Ana M Olivares, Bo Chang, Kaylee E Smith, Amy E Birsner, Robert J D'Amato, Norman A Michaud, Yinan Han, Demetrios G Vavvas, Joan W Miller, Neena B Haider, and Kip M Connor

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C57BL/6J congenic Prp-TDP43A315T mice develop progressive neurodegeneration in the myenteric plexus of the colon without exhibiting key features of ALS., Theo Hatzipetros, Laurent P. Bogdanik, Valerie R Tassinari, Joshua D Kidd, Andy J Moreno, Crystal Davis, Melissa Osborne, Andrew Austin, Fernando G Vieira, Cathleen Lutz, and Steve Perrin

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Meiosis-Specific Cohesin Component, Stag3 Is Essential for Maintaining Centromere Chromatid Cohesion, and Required for DNA Repair and Synapsis between Homologous Chromosomes., Jessica Hopkins, Grace Hwang, Justin Jacob, Nicklas Sapp, Rick Bedigian, Kazuhiro Oka, Paul Overbeek, Stephen A. Murray, and Philip W Jordan

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Rhbdf2 mutations increase its protein stability and drive EGFR hyperactivation through enhanced secretion of amphiregulin., Vishnu Hosur, Kenneth R. Johnson, Lisa M. Burzenski, Timothy M Stearns, Richard S. Maser, and Leonard D. Shultz

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Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma., Gareth R. Howell, Katharine H MacNicoll, Catherine E. Braine, Ileana Soto, Danilo G Macalinao, Gregory L Sousa, and Simon W M John

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OMIT: Dynamic, Semi-Automated Ontology Development for the microRNA Domain., Jingshan Huang, Jiangbo Dang, Glen M Borchert, Karen Eilbeck, He Zhang, Min Xiong, Weijian Jiang, Hao Wu, Judith A. Blake, Darren A Natale, and Ming Tan

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Identification of novel genes associated with renal tertiary lymphoid organ formation in aging mice., Yuan Huang, Christina R Caputo, Gerda A Noordmans, Saleh Yazdani, Luiz Henrique Monteiro, Jaap van den Born, Harry van Goor, Peter Heeringa, Ron Korstanje, and Jan-Luuk Hillebrands

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A method for increasing expressivity of Gene Ontology annotations using a compositional approach., Rachael P Huntley, Midori A Harris, Yasmin Alam-Faruque, Judith A. Blake, Seth Carbon, Heiko Dietze, Emily C Dimmer, Rebecca E Foulger, David P. Hill, Varsha K Khodiyar, Antonia Lock, Jane Lomax, Ruth C Lovering, Prudence Mutowo-Meullenet, Tony Sawford, Kimberly Van Auken, Valerie Wood, and Christopher J Mungall

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Systems consequences of amplicon formation in human breast cancer., Koichiro Inaki, Francesca Menghi, Xing Yi Woo, Joel P. Wagner, Pierre-Étienne Jacques, Yi Fang Lee, Phung Trang Shreckengast, Wendy WeiJia Soon, Ankit Malhotra, Audrey S M Teo, Axel M Hillmer, Alexis Jiaying Khng, Xiaoan Ruan, Swee Hoe Ong, Denis Bertrand, Niranjan Nagarajan, R Krishna Murthy Karuturi, Alfredo Hidalgo Miranda, and Edison T. Liu

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Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements., Tsuyoshi Inoue, Takahide Kohro, Toshiya Tanaka, Yasuharu Kanki, Guoliang Li, Huay-Mei Poh, Imari Mimura, Mika Kobayashi, Akashi Taguchi, Takashi Maejima, Jun-Ichi Suehiro, Akira Sugiyama, Kiyomi Kaneki, Hirofumi Aruga, Shoulian Dong, Junko F Stevens, Shogo Yamamoto, Shuichi Tsutsumi, Toshiro Fujita, Xiaoan Ruan, Hiroyuki Aburatani, Masaomi Nangaku, Yijun Ruan, Tatsuhiko Kodama, and Youichiro Wada

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RNA function. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration., Ryuta Ishimura, Gabor Nagy, Ivan Dotu, Huihao Zhou, Xiang-Lei Yang, Paul Schimmel, Satoru Senju, Yasuharu Nishimura, Jeffrey H. Chuang, and Susan L. Ackerman

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A Mathematical Model of Skeletal Muscle Disease and Immune Response in the mdx Mouse., Abdul Salam Jarrah, Filippo Castiglione, Nicholas P Evans, Robert W Grange, and Reinhard Laubenbacher

Performing Integrative Functional Genomics Analysis in GeneWeaver.org., Jeremy Jay and Elissa J Chesler

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How chromatin looping and nuclear envelope attachment affect genome organization in eukaryotic cell nuclei., Hansjoerg Jerabek and Dieter W Heermann

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Transcriptional profiles of bovine in vivo pre-implantation development., Zongliang Jiang, Jiangwen Sun, Hong Dong, Oscar Luo, Xinbao Zheng, Craig Obergfell, Yong Tang, Jinbo Bi, Rachel O'Neill, Yijun Ruan, Jingbo Chen, and Xiuchun Cindy Tian

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Searching for the initiating site of the major capsid protein to generate virus-like particles for a novel laboratory mouse papillomavirus., Joongho Joh, Alfred B Jenson, Arvind Ingle, John P. Sundberg, and Shin-Je Ghim

Animal models of exfoliation syndrome, now and future., Simon W M John, Jeffrey M. Harder, John H Fingert, and Michael G Anderson

Hearing impairment in hypothyroid dwarf mice caused by mutations of the thyroid peroxidase gene., Kenneth R. Johnson, Leona H. Gagnon, Chantal M. Longo-Guess, Belinda S. Harris, and Bo Chang

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Characterization of mutations in the PAS domain of the EvgS sensor kinase selected by laboratory evolution for acid resistance in Escherichia coli., Matthew D Johnson, James Bell, Kim Clarke, Rachel Chandler, Prachi Pathak, Yandong Xia, Robert L Marshall, George M. Weinstock, Nicholas J Loman, Peter J Winn, and Peter A Lund

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How low do you go? Decoding immunodeficient mouse models., Dominique Kagele

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Prom1 function in development, intestinal inflammation, and intestinal tumorigenesis., Baktiar O Karim, Ki-Jong Rhee, Guosheng Liu, Kyuson Yun, and Steven R Brant

Integrative genetic analysis of allergic inflammation in the murine lung., Samir N P Kelada, Danielle E Carpenter, David L Aylor, Peter Chines, Holly Rutledge, Elissa J. Chesler, Gary A. Churchill, Fernando Pardo-Manuel de Villena, David A Schwartz, and Francis S Collins

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Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel Loci in the genetic regulation of bone mass attainment., John P Kemp, Carolina Medina-Gomez, Karol Estrada, Beate St Pourcain, Denise H M Heppe, Nicole M Warrington, Ling Oei, Susan M Ring, Claudia J Kruithof, Nicholas J Timpson, Lisa E Wolber, Sjur Reppe, Kaare Gautvik, Elin Grundberg, Bing Ge, Bram van der Eerden, Jeroen van de Peppel, Matthew A. Hibbs, Cheryl L Ackert-Bicknell, Kwangbom Choi, Daniel L Koller, Michael J Econs, Frances M K Williams, Tatiana Foroud, M Carola Zillikens, Claes Ohlsson, Albert Hofman, André G Uitterlinden, George Davey Smith, Vincent W V Jaddoe, Jonathan H Tobias, Fernando Rivadeneira, and David M Evans

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Lack of Response to Laser Comb in Spontaneous and Graft-Induced Alopecia Areata in C3H/HeJ Mice., Lloyd E King, Kathleen A. Silva, Victoria E. Kennedy, and John P. Sundberg

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Schlemm's Canal Is a Unique Vessel with a Combination of Blood Vascular and Lymphatic Phenotypes that Forms by a Novel Developmental Process., Krishnakumar Kizhatil, Margaret Ryan, Jeffrey K Marchant, Stephen Henrich, and Simon W M John

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An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia., Birgit Knoechel, Justine E Roderick, Kaylyn E Williamson, Jiang Zhu, Jens G Lohr, Matthew J Cotton, Shawn M Gillespie, Daniel Fernandez, Manching Ku, Hongfang Wang, Federica Piccioni, Serena J Silver, Mohit Jain, Daniel Pearson, Michael J Kluk, Christopher J Ott, Leonard D. Shultz, Michael A Brehm, Dale L Greiner, Alejandro Gutierrez, Kimberly Stegmaier, Andrew L Kung, David E Root, James E Bradner, Jon C Aster, Michelle A Kelliher, and Bradley E Bernstein

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The wistar legacy to embryonic stem cell research., Barbara B. Knowles

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Exome-Based Mapping and Variant Prioritization for Inherited Mendelian Disorders., Daniel C Koboldt, David E Larson, Lori S Sullivan, Sara J Bowne, Karyn M Steinberg, Jennifer D Churchill, Aimee C Buhr, Nathan Nutter, Eric A Pierce, Susan H Blanton, George M. Weinstock, Richard K Wilson, and Stephen P Daiger