Title

Genetically engineered humanized mouse models for preclinical antibody studies.

Document Type

Article

Publication Date

4-2014

JAX Location

Reprint Collection

JAX Source

BioDrugs 2014 Apr; 28(2):171-80.

PMID

24150980

Abstract

The use of genetic engineering has vastly improved our capabilities to create animal models relevant in preclinical research. With the recent advances in gene-editing technologies, it is now possible to very rapidly create highly tunable mouse models as needs arise. Here, we provide an overview of genetic engineering methods, as well as the development of humanized neonatal Fc receptor (FcRn) models and their use for monoclonal antibody in vivo studies.

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