Memory programming in CD8(+) T-cell differentiation is intrinsic and is not determined by CD4 help.
Document Type
Article
Publication Date
8-14-2015
JAX Source
Nat Commun 2015 Aug 14; 6:7994.
Volume
6
First Page
7994
Last Page
7994
ISSN
2041-1723
PMID
26272364
Abstract
CD8(+) T cells activated without CD4(+) T-cell help are impaired in memory expansion. To understand the underlying cellular mechanism, here we track the dynamics of helper-deficient CD8(+) T-cell response to a minor histocompatibility antigen by phenotypic and in vivo imaging analyses. Helper-deficient CD8(+) T cells show reduced burst expansion, rapid peripheral egress, delayed antigen clearance and continuous activation, and are eventually exhausted. Contrary to the general consensus that CD4 help encodes memory programmes in CD8(+) T cells and helper-deficient CD8(+) T cells are abortive, these cells can differentiate into effectors and memory precursors. Importantly, accelerating antigen clearance or simply increasing the burst effector size enables generation of memory cells by CD8(+) T cells, regardless of CD4 help. These results suggest that the memory programme is CD8(+) T-cell-intrinsic, and provide insight into the role of CD4 help in CD8(+) T-cell responses. Nat Commun 2015 Aug 14; 6:7994.
Recommended Citation
Kim J,
Jeong Ryu S,
Oh K,
Ju J,
Yeong Jeon J,
Nam G,
Lee D,
Kim H,
Young Kim J,
Chang J,
Sproule TJ,
Choi K,
Roopenian DC,
Young Choi E.
Memory programming in CD8(+) T-cell differentiation is intrinsic and is not determined by CD4 help. Nat Commun 2015 Aug 14; 6:7994.