Application of comparative biology in GO functional annotation: the mouse model.
Document Type
Article
Publication Date
10-2015
JAX Source
Mamm Genome 2015 Oct; 26(9-10):574-83.
Volume
26
Issue
9-10
First Page
574
Last Page
583
ISSN
1432-1777
PMID
26141960
Abstract
The Gene Ontology (GO) is an important component of modern biological knowledge representation with great utility for computational analysis of genomic and genetic data. The Gene Ontology Consortium (GOC) consists of a large team of contributors including curation teams from most model organism database groups as well as curation teams focused on representation of data relevant to specific human diseases. Key to the generation of consistent and comprehensive annotations is the development and use of shared standards and measures of curation quality. The GOC engages all contributors to work to a defined standard of curation that is presented here in the context of annotation of genes in the laboratory mouse. Comprehensive understanding of the origin, epistemology, and coverage of GO annotations is essential for most effective use of GO resources. Here the application of comparative approaches to capturing functional data in the mouse system is described. Mamm Genome 2015 Oct; 26(9-10):574-83.
Recommended Citation
Drabkin HJ,
Christie KR,
Dolan ME,
Hill DP,
Ni L,
Sitnikov D,
Blake JA.
Application of comparative biology in GO functional annotation: the mouse model. Mamm Genome 2015 Oct; 26(9-10):574-83.