Title

The transcriptional landscape of age in human peripheral blood.

Authors

Marjolein J Peters
Roby Joehanes
Luke C Pilling
Claudia Schurmann
Karen N Conneely
Joseph Powell
Eva Reinmaa
George L. Sutphin, The Jackson LaboratoryFollow
Alexandra Zhernakova
Katharina Schramm
Yana A Wilson
Sayuko Kobes
Taru Tukiainen
Yolande F Ramos
Harald H H Göring
Myriam Fornage
Yongmei Liu
Sina A Gharib
Barbara E Stranger
Philip L De Jager
Abraham Aviv
Daniel Levy
Joanne M Murabito
Peter J Munson
Tianxiao Huan
Albert Hofman
André G Uitterlinden
Fernando Rivadeneira
Jeroen van Rooij
Lisette Stolk
Linda Broer
Michael M P J Verbiest
Mila Jhamai
Pascal Arp
Andres Metspalu
Liina Tserel
Lili Milani
Nilesh J Samani
Pärt Peterson
Silva Kasela
Veryan Codd
Annette Peters
Cavin K Ward-Caviness
Christian Herder
Melanie Waldenberger
Michael Roden
Paula Singmann
Sonja Zeilinger
Thomas Illig
Georg Homuth
Hans-Jörgen Grabe
Henry Völzke
Leif Steil
Thomas Kocher
Anna Murray
David Melzer
Hanieh Yaghootkar
Stefania Bandinelli
Eric K Moses
Jack W Kent
Joanne E Curran
Matthew P Johnson
Sarah Williams-Blangero
Harm-Jan Westra
Allan F McRae
Jennifer A Smith
Sharon L R Kardia
Iiris Hovatta
Markus Perola
Samuli Ripatti
Veikko Salomaa
Anjali K Henders
Nicholas G Martin
Alicia K Smith
Divya Mehta
Elisabeth B Binder
K Maria Nylocks
Elizabeth M Kennedy
Torsten Klengel
Jingzhong Ding
Astrid M Suchy-Dicey
Daniel A Enquobahrie
Jennifer Brody
Jerome I Rotter
Yii-Der I Chen
Jeanine Houwing-Duistermaat
Margreet Kloppenburg
P Eline Slagboom
Quinta Helmer
Wouter den Hollander
Shannon Bean
Towfique Raj
Noman Bakhshi
Qiao Ping Wang
Lisa J Oyston
Bruce M Psaty
Russell P Tracy
Grant W Montgomery
Stephen T Turner
John Blangero
Ingrid Meulenbelt
Kerry J Ressler
Jian Yang
Lude Franke
Johannes Kettunen
Peter M Visscher
G Gregory Neely
Ron Korstanje, The Jackson LaboratoryFollow
Robert L Hanson
Holger Prokisch
Luigi Ferrucci
Tonu Esko
Alexander Teumer
Joyce B J van Meurs
Andrew D Johnson

Document Type

Article

Publication Date

10-22-2015

JAX Source

Nat Commun 2015 Oct 22; 6:8570.

PMID

26490707

Abstract

Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the 'transcriptomic age' of an individual, and show that differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index. The transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models, and can be used by others to calculate transcriptomic age in external cohorts. Nat Commun 2015 Oct 22; 6:8570.