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Submissions from 2016

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Mining biomedical images towards valuable information retrieval in biomedical and life sciences., Zeeshan Ahmed, Saman Zeeshan, and Thomas Dandekar

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Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary., Ramesh Akkina, Atef Allam, Alejandro B Balazs, Joel N Blankson, John C Burnett, Sofia Casares, J Victor Garcia, Kim J Hasenkrug, Fatah Kashanchi, Scott G Kitchen, Florian Klein, Priti Kumar, Andrew D Luster, Larisa Y Poluektova, Mangala Rao, Brigitte E Sanders-Beer, Leonard D. Shultz, and Jerome A Zack

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Col4a1 mutations cause progressive retinal neovascular defects and retinopathy., Marcel V Alavi, Mao Mao, Bradley T Pawlikowski, Manana Kvezereli, Jacque L Duncan, Richard T Libby, Simon W M John, and Douglas B Gould

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Genetically modified human CD4(+) T cells can be evaluated in vivo without lethal graft-versus-host disease., Riyasat Ali, Jeffrey Babad, Antonia Follenzi, John A Gebe, Michael A Brehm, Gerald T Nepom, Leonard D. Shultz, Dale L Greiner, and Teresa P DiLorenzo

Retrospective Evaluation of Nail Trimming as a Conservative Treatment for Ulcerative Dermatitis in Laboratory Mice., Cynthia G Alvarado, Craig L Franklin, and Lonny W Dixon

Splicing-factor alterations in cancers., Olga Anczuków and Adrian R Krainer

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Dynamin 1 isoform roles in a mouse model of severe childhood epileptic encephalopathy., Samuel Asinof, Connie L Mahaffey, Barbara Beyer, Wayne N Frankel, and Rebecca M. Boumil

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Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma., Jessica N Cooke Bailey, Stephanie J Loomis, Jae H Kang, R Rand Allingham, Puya Gharahkhani, Chiea Chuen Khor, Kathryn P Burdon, Hugues Aschard, Daniel I Chasman, Robert P Igo, Pirro G Hysi, Craig A Glastonbury, Allison Ashley-Koch, Murray Brilliant, Andrew A Brown, Donald L Budenz, Alfonso Buil, Ching-Yu Cheng, Hyon Choi, William G Christen, Gary Curhan, Immaculata De Vivo, John H Fingert, Paul J Foster, Charles Fuchs, Douglas Gaasterland, Terry Gaasterland, Alex W Hewitt, Frank Hu, David J Hunter, Anthony P Khawaja, Richard K Lee, Zheng Li, Paul R Lichter, David A Mackey, Peter McGuffin, Paul Mitchell, Sayoko E Moroi, Shamira A Perera, Keating W. Pepper, Qibin Qi, Tony Realini, Julia E Richards, Paul M Ridker, Eric Rimm, Robert Ritch, Marylyn Ritchie, Joel S Schuman, William K Scott, Kuldev Singh, Arthur J Sit, Yeunjoo E Song, Rulla M Tamimi, Fotis Topouzis, Ananth C Viswanathan, Shefali Setia Verma, Douglas Vollrath, Jie Jin Wang, Nicole Weisschuh, Bernd Wissinger, Gadi Wollstein, Tien Y Wong, Brian L Yaspan, Donald J Zack, Kang Zhang, Epic-Norfolk Eye Study, Robert N Weinreb, Margaret A Pericak-Vance, Kerrin Small, Christopher J Hammond, Tin Aung, Yutao Liu, Eranga N Vithana, Stuart MacGregor, Jamie E Craig, Peter Kraft, Gareth R Howell, Michael A Hauser, Louis R Pasquale, Jonathan L Haines, and Janey L Wiggs

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Metabolite profile of a mouse model of Charcot-Marie-Tooth type 2D neuropathy: implications for disease mechanisms and interventions., Preeti Bais, Kirk Beebe, Kathryn H. Morelli, Meagan E Currie, Sara N Norberg, Alexei V Evsikov, Kathy E Miers, Kevin L. Seburn, Velina Guergueltcheva, Ivo Kremensky, Albena Jordanova, Carol J Bult, and Robert W. Burgess

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GeneWeaver: data driven alignment of cross-species genomics in biology and disease., Erich Baker, Jason A. Bubier, Timothy Reynolds, Michael A Langston, and Elissa J Chesler

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Regulatory complexity revealed by integrated cytological and RNA-seq analyses of meiotic substages in mouse spermatocytes., Robyn L Ball, Yasuhiro Fujiwara, Fengyun Sun, Jianjun Hu, Matthew A Hibbs, Mary Ann Handel, and Gregory W. Carter

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Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients., Romain Banchereau, Seunghee Hong, Brandi Cantarel, Nicole Baldwin, Jeanine Baisch, Michelle Edens, Alma-Martina Cepika, Peter Acs, Jacob Turner, Esperanza Anguiano, Parvathi Vinod, Shaheen Kahn, Gerlinde Obermoser, Derek Blankenship, Edward Wakeland, Lorien Nassi, Alisa Gotte, Marilynn Punaro, Yong-Jun Liu, Jacques Banchereau, Jose Rossello-Urgell, Tracey Wright, and Virginia Pascual

Natural genetic variation profoundly regulates gene expression in immune cells and dictates susceptibility to CNS autoimmunity., F Bearoff, R Del Rio, L K Case, J A Dragon, T Nguyen-Vu, C-Y Lin, E P Blankenhorn, C Teuscher, and D N Krementsov

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Temporal dynamics of the developing lung transcriptome in three common inbred strains of laboratory mice reveals multiple stages of postnatal alveolar development., Kyle J Beauchemin, Julie M Wells, Alvin T Kho, Vivek M. Philip, Daniela Kamir, Isaac S Kohane, Joel H. Graber, and Carol J Bult

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Enhancing the versatility of wireless biopotential acquisition for myoelectric prosthetic control., Rebecca A Bercich, Zhi Wang, Henry Mei, Lauren H Hammer, Kevin L. Seburn, Levi J Hargrove, and Pedro P Irazoqui

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Genetic determinants of fibro-osseous lesions in aged inbred mice., Annerose Berndt, Cheryl Ackert-Bicknell, Kathleen A Silva, Victoria E. Kennedy, Beth A. Sundberg, Justin M Cates, Paul N Schofield, and John P Sundberg

A 380-gene meta-signature of active tuberculosis compared with healthy controls., Simon Blankley, Christine M Graham, Joe Levin, Jacob Turner, Matthew P R Berry, Chloe I Bloom, Zhaohui Xu, Virgina Pascual, Jacques Banchereau, Damien Chaussabel, Ronan Breen, George Santis, Derek M Blankenship, Marc Lipman, and Anne O'Garra

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The Transcriptional Signature of Active Tuberculosis Reflects Symptom Status in Extra-Pulmonary and Pulmonary Tuberculosis., Simon Blankley, Christine M Graham, Jacob Turner, Matthew P R Berry, Chloe I Bloom, Zhaohui Xu, Virginia Pascual, Jacques Banchereau, Damien Chaussabel, Ronan Breen, George Santis, Derek M Blankenship, Marc Lipman, and Anne O'Garra

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Accessing Data Resources in the Mouse Phenome Database for Genetic Analysis of Murine Life Span and Health Span., Molly A. Bogue, Luanne L. Peters, Beverly J Paigen, Ron Korstanje, Rong Yuan, Cheryl Ackert-Bicknell, Stephen C. Grubb, Gary A. Churchill, and Elissa J Chesler

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The Mediator of Hematopoietic Stem Cell Homeostasis., Sneha Borikar and Jennifer J. Trowbridge

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Cell-Extrinsic MHC Class I Molecule Engagement Augments Human NK Cell Education Programmed by Cell-Intrinsic MHC Class I., Jeanette E Boudreau, Xiao-Rong Liu, Zeguo Zhao, Aaron Zhang, Leonard D. Shultz, Dale L Greiner, Bo Dupont, and Katharine C Hsu

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NIH working group report-using genomic information to guide weight management: From universal to precision treatment., Molly S Bray, Ruth J F Loos, Jeanne M McCaffery, Charlotte Ling, Paul W Franks, George M. Weinstock, Michael P Snyder, Jason L Vassy, and Tanya Agurs-Collins

Assessment of the Readability of Genetic Counseling Patient Letters., Emily Brown, Megan Skinner, Stephanie Ashley, Kate Reed, and Shannan DeLany Dixon

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Humanized mouse model of mast cell-mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis., Paul J Bryce, Rustom Falahati, Laurie L Kenney, John Leung, Christopher Bebbington, Nenad Tomasevic, Rebecca A Krier, Chia-Lin Hsu, Leonard D Shultz, Dale L Greiner, and Michael A Brehm

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Cross-Species Integrative Functional Genomics in GeneWeaver Reveals a Role for Pafah1b1 in Altered Response to Alcohol., Jason A. Bubier, Troy Wilcox, Jeremy Jay, Michael A Langston, Erich J Baker, and Elissa J Chesler

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Mouse genome database 2016., Carol J Bult, Janan T. Eppig, Judith A. Blake, James A. Kadin, and Joel E Richardson

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Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease., Aaron Burberry, Naoki Suzuki, Jin-Yuan Wang, Rob Moccia, Daniel A Mordes, Morag H Stewart, Satomi Suzuki-Uematsu, Sulagna Ghosh, Ajay Singh, Florian T Merkle, Kathryn Koszka, Quan-Zhen Li, Leonard Zon, Derrick J Rossi, Jennifer J. Trowbridge, Luigi D Notarangelo, and Kevin Eggan

Neuromuscular Disease Models and Analysis., Robert W. Burgess, Gregory A. Cox, and Kevin L. Seburn

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Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus., Simone Caielli, Shruti Athale, Bojana Domic, Elise Murat, Manjari Chandra, Romain Banchereau, Jeanine Baisch, Kate Phelps, Sandra Clayton, Mei Gong, Tracey Wright, Marilynn Punaro, Karolina Palucka, Cristiana Guiducci, Jacques Banchereau, and Virginia Pascual

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Bridging channel dendritic cells induce immunity to transfused red blood cells., Samuele Calabro, Antonia Gallman, Uthaman Gowthaman, Dong Liu, Pei Chen, Jingchun Liu, Jayendra Kumar Krishnaswamy, Manuela Sales L Nascimento, Lan Xu, Seema R Patel, Adam Williams, Christopher A Tormey, Eldad A Hod, Steven L Spitalnik, James C Zimring, Jeanne E Hendrickson, Sean R Stowell, and Stephanie C Eisenbarth

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Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity., Samuele Calabro, Dong Liu, Antonia Gallman, Manuela Sales L Nascimento, Zizi Yu, Ting-Ting Zhang, Pei Chen, Biyan Zhang, Lan Xu, Uthaman Gowthaman, Jayendra Kumar Krishnaswamy, Ann M Haberman, Adam Williams, and Stephanie C Eisenbarth

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Abnormal response of distal Schwann cells to denervation in a mouse model of motor neuron disease., Dario I Carrasco, Ben A Bahr, Kevin L. Seburn, and Martin J Pinter

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Altered terminal Schwann cell morphology precedes denervation in SOD1 mice., Dario I Carrasco, Kevin L. Seburn, and Martin J Pinter

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Long-term clinical follow-up and molecular testing for diagnosis of the first Tunisian family with Alström syndrome., Amine Chakroun, Mariem Ben Said, Amine Ennouri, Imen Achour, Mouna Mnif, Mohamed Abid, Abdelmonem Ghorbel, Jan D. Marshall, Juergen K. Naggert, and Saber Masmoudi

Mouse Models as Tools to Identify Genetic Pathways for Retinal Degeneration, as Exemplified by Leber's Congenital Amaurosis., Bo Chang

A Chemical Mutagenesis Screen Identifies Mouse Models with ERG Defects., Jeremy R. Charette, Ivy S Samuels, Minzhong Yu, Lisa Stone, Wanda L. Hicks, Lan Ying Shi, Mark P. Krebs, Juergen K. Naggert, Patsy M. Nishina, and Neal S Peachey

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Casilio: a versatile CRISPR-Cas9-Pumilio hybrid for gene regulation and genomic labeling., Albert W. Cheng, Nathaniel L. Jillette, Phoebe Lee, Dylan Plaskon, Yasuhiro Fujiwara, Wenbo Wang, Aziz Taghbalout, and Haoyi Wang

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Combined B, T and NK Cell Deficiency Accelerates Atherosclerosis in BALB/c Mice., Fei Cheng, Laura Twardowski, Kurt Reifenberg, Kerstin Winter, Antje Canisius, Eva Pross, Jianglin Fan, Edgar Schmitt, Leonard D. Shultz, Karl J Lackner, and Michael Torzewski

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Single-cell multimodal profiling reveals cellular epigenetic heterogeneity., Lih Feng Cheow, Elise T Courtois, Yuliana Tan, Ramya Viswanathan, Qiaorui Xing, Rui Zhen Tan, Daniel S W Tan, Paul Robson, Yuin-Han Loh, Stephen R Quake, and William F Burkholder

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Diversity Outbred Mice at 21: Maintaining Allelic Variation in the Face of Selection., Elissa J Chesler, Daniel Mario Gatti, Andrew P Morgan, Marjorie Strobel, Laura Trepanier, Denesa Oberbeck, Shannon McWeeney, Robert Hitzemann, Martin Ferris, Rachel McMullan, Amelia Clayshultle, Timothy A Bell, Fernando Pardo Manuel de Villena, and Gary A. Churchill

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Defining the consequences of genetic variation on a proteome-wide scale., Joel M Chick, Steven C. Munger, Petr Simecek, Edward L Huttlin, Kwangbom Choi, Daniel M. Gatti, Narayanan Raghupathy, Karen L. Svenson, Gary Churchill, and Steven P Gygi

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An Integrative Approach to Precision Cancer Medicine Using Patient-Derived Xenografts., Sung-Yup Cho, Wonyoung Kang, Jee Yun Han, Seoyeon Min, Jinjoo Kang, Ahra Lee, Jee Young Kwon, Charles Lee, and Hansoo Park

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Eric Lander and David Botstein on Mapping Quantitative Traits., Gary A. Churchill

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Tumor-derived circulating endothelial cell clusters in colorectal cancer., Igor Cima, Say Li Kong, Debarka Sengupta, Iain B Tan, Wai Min Phyo, Daniel Lee, Min Hu, Ciprian Iliescu, Irina Alexander, Wei Lin Goh, Mehran Rahmani, Nur-Afidah Mohamed Suhaimi, Jess H Vo, Joyce A Tai, Joanna H Tan, Clarinda Chua, Rachel Ten, Wan Jun Lim, Min Hoe Chew, Charlotte A E Hauser, Rob M van Dam, Wei-Yen Lim, Shyam Prabhakar, Bing Lim, Poh Koon Koh, Paul Robson, Jackie Y Ying, Axel M Hillmer, and Min-Han Tan

Pituitary morphovolumetric changes in Alström syndrome., Valentina Citton, Pietro Maffei, Jan D. Marshall, Alessandro Baglione, Gayle B. Collin, Gabriella Milan, Roberto Vettor, Juergen K. Naggert, and Renzo Manara

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Onco-Hu™ Models: Humanized NSG™ and NSG™-SGM3 Mice for Immuno-Oncology, JAX Mice, Clinical and Research Services

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Effect of genetic background on the dystrophic phenotype in mdx mice., William D Coley, Laurent P. Bogdanik, Maria Candida Vila, Qing Yu, Jack H Van Der Meulen, Sree Rayavarapu, James S Novak, Marie Nearing, James L Quinn, Allison Saunders, Connor Dolan, Whitney Andrews, Catherine Lammert, Andrew Austin, Terence A Partridge, Gregory A. Cox, Cathleen Lutz, and Kanneboyina Nagaraju

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Analysis of morphine responses in mice reveals a QTL on Chromosome 7., Wim E Crusio, Esha Dhawan, Elissa J Chesler, and Anna Delprato

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HSF1: Guardian of Proteostasis in Cancer., Chengkai Dai and Stephen B. Sampson

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Stress-impaired transcription factor expression and insulin secretion in transplanted human islets., Chunhua Dai, Nora S Kayton, Alena Shostak, Greg Poffenberger, Holly A Cyphert, Radhika Aramandla, Courtney Thompson, Ioannis G Papagiannis, Christopher Emfinger, Masakazu Shiota, John M Stafford, Dale L Greiner, Pedro L Herrera, Leonard D. Shultz, Roland Stein, and Alvin C Powers

Identification of a Novel Gene on 10q22.1 Causing Autosomal Dominant Retinitis Pigmentosa (adRP)., Stephen P Daiger, Lori S Sullivan, Sara J Bowne, Daniel C Koboldt, Susan H Blanton, Dianna K Wheaton, Cheryl E Avery, Elizabeth D Cadena, Robert K Koenekoop, Robert S Fulton, Richard K Wilson, George M. Weinstock, Richard A Lewis, and David G Birch

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Development-on-chip: in vitro neural tube patterning with a microfluidic device., Christopher J Demers, Prabakaran Soundararajan, Phaneendra Chennampally, Gregory A. Cox, James Briscoe, Scott D Collins, and Rosemary L Smith

Symbiotic Burkholderia Species Show Diverse Arrangements of nif/fix and nod Genes and Lack Typical High-Affinity Cytochrome cbb3 Oxidase Genes., Sofie E De Meyer, Leah Briscoe, Pilar Martínez-Hidalgo, Christina M Agapakis, Paulina Estrada de-Los Santos, Rekha Seshadri, Wayne Reeve, George M. Weinstock, Graham O'Hara, John G Howieson, and Ann M Hirsch

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High-throughput discovery of novel developmental phenotypes., Mary E Dickinson, Ann M Flenniken, Xiao Ji, Lydia Teboul, Michael D Wong, Jacqueline K White, Terrence F Meehan, Wolfgang J Weninger, Henrik Westerberg, Hibret Adissu, Candice N Baker, Lynette Bower, James M Brown, L Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R Horner, Chih-Wei Hsu, Sara J Johnson, Sowmya Kalaga, Lance C Keith, Louise Lanoue, Thomas N Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L McElwee, Susan Newbigging, Lauryl M J Nutter, Kevin A Peterson, Ramiro Ramirez-Solis, Douglas J Rowland, Edward Ryder, Kaitlin E Samocha, John R Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B West, Leeyean Wong, Atsushi Yoshiki, Daniel G MacArthur, Glauco P Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C Skarnes, Monica J Justice, Helen E Parkinson, Mark Moore, Sara Wells, Robert E Braun, Karen L Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R Mark Henkelman, Steve D M Brown, David J Adams, K C Kent Lloyd, Colin McKerlie, Arthur L Beaudet, Maja Bućan, and Stephen A Murray

Systems genetics of intravenous cocaine self-administration in the BXD recombinant inbred mouse panel., Price E. Dickson, Mellessa M Miller, Michele A Calton, Jason A. Bubier, Melloni N Cook, Daniel Goldowitz, Elissa J. Chesler, and Guy Mittleman

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R2d2 drives selfish sweeps in the house mouse., John P Didion, Andrew P Morgan, Liran Yadgary, Timothy A Bell, Rachel C McMullan, Lydia Ortiz de Solorzano, Janice Britton-Davidian, Carol J Bult, Karl J Campbell, Riccardo Castiglia, Yung-Hao Ching, Amanda J Chunco, James J Crowley, Elissa J Chesler, Daniel W Förster, John E French, Sofia I Gabriel, Daniel Mario Gatti, Theodore Garland, Eva B Giagia-Athanasopoulou, Mabel D Giménez, Sofia A Grize, Islam Gündüz, Andrew Holmes, Heidi C Hauffe, Jeremy S Herman, James M Holt, Kunjie Hua, Wesley J Jolley, Anna K Lindholm, María J López-Fuster, George Mitsainas, Maria da Luz Mathias, Leonard McMillan, M Graça Ramalhinho, Barbara Rehermann, Stephan P Rosshart, Jeremy B Searle, Meng-Shin Shiao, Emanuela Solano, Karen L Svenson, Pat Thomas-Laemont, David W Threadgill, Jacint Ventura, George M. Weinstock, Daniel Pomp, Gary Churchill, and Fernando Pardo-Manuel de Villena

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The Cell Ontology 2016: enhanced content, modularization, and ontology interoperability., Alexander D Diehl, Terrence F Meehan, Yvonne M Bradford, Matthew H Brush, Wasila M Dahdul, David S Dougall, Yongqun He, David Osumi-Sutherland, Alan Ruttenberg, Sirarat Sarntivijai, Ceri E Van Slyke, Nicole A Vasilevsky, Melissa A Haendel, Judith A. Blake, and Christopher J Mungall

Somatic gene mutation analysis of triple negative breast cancers., J L Dillon, Susan Mockus, Guruprasad Ananda, Vanessa Spotlow, W A Wells, Gregory J Tsongalis, and J D Marotti

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N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice., Dalian Ding, Haiyan Jiang, Guang-Di Chen, Chantal M. Longo-Guess, Vijaya Prakash Krishnan Muthaiah, Cong Tian, Adam Sheppard, Richard Salvi, and Kenneth R. Johnson

Patient-derived xenograft (PDX) models in basic and translational breast cancer research., Lacey E Dobrolecki, Susan D Airhart, Denis G Alferez, Samuel Aparicio, Fariba Behbod, Mohamed Bentires-Alj, Cathrin Brisken, Carol J Bult, Shirong Cai, Robert B Clarke, Heidi Dowst, Matthew J Ellis, Eva Gonzalez-Suarez, Richard D Iggo, Peter Kabos, Shunqiang Li, Geoffrey J Lindeman, Elisabetta Marangoni, Aaron McCoy, Funda Meric-Bernstam, Helen Piwnica-Worms, Marie-France Poupon, Jorge Reis-Filho, Carol A Sartorius, Valentina Scabia, George Sflomos, Yizheng Tu, François Vaillant, Jane E Visvader, Alana Welm, Max S Wicha, and Michael T Lewis

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Novel axon projection after stress and degeneration in the Dscam mutant retina., K A Fernandes, S J Bloomsburg, C J Miller, S A Billingslea, M M Merrill, Robert W. Burgess, R T Libby, and P G Fuerst

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DermO; an ontology for the description of dermatologic disease., Hannah M Fisher, Robert Hoehndorf, Bruno S Bazelato, Soheil S Dadras, Lloyd E King, Georgios V Gkoutos, John P Sundberg, and Paul N Schofield

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Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet-induced obesity and insulin resistance., Randall H Friedline, Hwi Jin Ko, Dae Young Jung, Yongjin Lee, Rita Bortell, Sezin Dagdeviren, Payal R Patel, Xiaodi Hu, Kunikazu Inashima, Caitlyn Kearns, Nicholas Tsitsilianos, Umber Shafiq, Leonard D. Shultz, Ki Won Lee, Dale L Greiner, and Jason K Kim

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The genetic architecture of type 2 diabetes., Christian Fuchsberger, Jason Flannick, Tanya M Teslovich, Anubha Mahajan, Vineeta Agarwala, Kyle J Gaulton, Clement Ma, Pierre Fontanillas, Loukas Moutsianas, Davis J McCarthy, Manuel A Rivas, John R B Perry, Xueling Sim, Thomas W Blackwell, Neil R Robertson, N William Rayner, Pablo Cingolani, Adam E Locke, Juan Fernandez Tajes, Heather M Highland, Josee Dupuis, Peter S Chines, Cecilia M Lindgren, Christopher Hartl, Anne U Jackson, Han Chen, Jeroen R Huyghe, Martijn van de Bunt, Richard D Pearson, Ashish Kumar, Martina Müller-Nurasyid, Niels Grarup, Heather M Stringham, Eric R Gamazon, Jaehoon Lee, Yuhui Chen, Robert A Scott, Jennifer E Below, Peng Chen, Jinyan Huang, Min Jin Go, Michael L. Stitzel, Dorota Pasko, Stephen C J Parker, Tibor V Varga, Todd Green, Nicola L Beer, Aaron G Day-Williams, Teresa Ferreira, Tasha Fingerlin, Momoko Horikoshi, Cheng Hu, Iksoo Huh, Mohammad Kamran Ikram, Bong-Jo Kim, Yongkang Kim, Young Jin Kim, Min-Seok Kwon, Juyoung Lee, Selyeong Lee, Keng-Han Lin, Taylor J Maxwell, Yoshihiko Nagai, Xu Wang, Ryan P Welch, Joon Yoon, Weihua Zhang, Nir Barzilai, Benjamin F Voight, Bok-Ghee Han, Christopher P Jenkinson, Teemu Kuulasmaa, Johanna Kuusisto, Alisa Manning, Maggie C Y Ng, Nicholette D Palmer, Beverley Balkau, Alena Stancáková, Hanna E Abboud, Heiner Boeing, Vilmantas Giedraitis, Dorairaj Prabhakaran, Omri Gottesman, James Scott, Jason Carey, Phoenix Kwan, George Grant, Joshua D Smith, Benjamin M Neale, Shaun Purcell, Adam S Butterworth, Joanna M M Howson, Heung Man Lee, Yingchang Lu, Soo-Heon Kwak, Wei Zhao, John Danesh, Vincent K L Lam, Kyong Soo Park, Danish Saleheen, Wing Yee So, Claudia H T Tam, Uzma Afzal, David Aguilar, Rector Arya, Tin Aung, Edmund Chan, Carmen Navarro, Ching-Yu Cheng, Domenico Palli, Adolfo Correa, Joanne E Curran, Denis Rybin, Vidya S Farook, Sharon P Fowler, Barry I Freedman, Michael Griswold, Daniel Esten Hale, Pamela J Hicks, Chiea-Chuen Khor, Satish Kumar, Benjamin Lehne, Dorothée Thuillier, Wei Yen Lim, Jianjun Liu, Yvonne T van der Schouw, Marie Loh, Solomon K Musani, Sobha Puppala, William R Scott, Loïc Yengo, Sian-Tsung Tan, Herman A Taylor, Farook Thameem, Gregory Wilson, Tien Yin Wong, Pål Rasmus Njølstad, Jonathan C Levy, Massimo Mangino, Lori L Bonnycastle, Thomas Schwarzmayr, João Fadista, Gabriela L Surdulescu, Christian Herder, Christopher J Groves, Thomas Wieland, Jette Bork-Jensen, Ivan Brandslund, Cramer Christensen, Heikki A Koistinen, Alex S F Doney, Leena Kinnunen, Tõnu Esko, Andrew J Farmer, Liisa Hakaste, Dylan Hodgkiss, Jasmina Kravic, Valeriya Lyssenko, Mette Hollensted, Marit E Jørgensen, Torben Jørgensen, Claes Ladenvall, Johanne Marie Justesen, Annemari Käräjämäki, Jennifer Kriebel, Wolfgang Rathmann, Lars Lannfelt, Torsten Lauritzen, Narisu Narisu, Allan Linneberg, Olle Melander, Lili Milani, Matt Neville, Marju Orho-Melander, Lu Qi, Qibin Qi, Michael Roden, Olov Rolandsson, Amy Swift, Anders H Rosengren, Kathleen Stirrups, Andrew R Wood, Evelin Mihailov, Christine Blancher, Mauricio O Carneiro, Jared Maguire, Ryan Poplin, Khalid Shakir, Timothy Fennell, Mark DePristo, Martin Hrabé de Angelis, Panos Deloukas, Anette P Gjesing, Goo Jun, Peter Nilsson, Jacquelyn Murphy, Robert Onofrio, Barbara Thorand, Torben Hansen, Christa Meisinger, Frank B Hu, Bo Isomaa, Fredrik Karpe, Liming Liang, Annette Peters, Cornelia Huth, Stephen P O'Rahilly, Colin N A Palmer, Oluf Pedersen, Rainer Rauramaa, Jaakko Tuomilehto, Veikko Salomaa, Richard M Watanabe, Ann-Christine Syvänen, Richard N Bergman, Dwaipayan Bharadwaj, Erwin P Bottinger, Yoon Shin Cho, Giriraj R Chandak, Juliana C N Chan, Kee Seng Chia, Mark J Daly, Shah B Ebrahim, Claudia Langenberg, Paul Elliott, Kathleen A Jablonski, Donna M Lehman, Weiping Jia, Ronald C W Ma, Toni I Pollin, Manjinder Sandhu, Nikhil Tandon, Philippe Froguel, Inês Barroso, Yik Ying Teo, Eleftheria Zeggini, Ruth J F Loos, Kerrin S Small, Janina S Ried, Ralph A DeFronzo, Harald Grallert, Benjamin Glaser, Andres Metspalu, Nicholas J Wareham, Mark Walker, Eric Banks, Christian Gieger, Erik Ingelsson, Hae Kyung Im, Thomas Illig, Paul W Franks, Gemma Buck, Joseph Trakalo, David Buck, Inga Prokopenko, Reedik Mägi, Lars Lind, Yossi Farjoun, Katharine R Owen, Anna L Gloyn, Konstantin Strauch, Tiinamaija Tuomi, Jaspal Singh Kooner, Jong-Young Lee, Taesung Park, Peter Donnelly, Andrew D Morris, Andrew T Hattersley, Donald W Bowden, Francis S Collins, Gil Atzmon, John C Chambers, Timothy D Spector, Markku Laakso, Tim M Strom, Graeme I Bell, John Blangero, Ravindranath Duggirala, E Shyong Tai, Gilean McVean, Craig L Hanis, James G Wilson, Mark Seielstad, Timothy M Frayling, James B Meigs, Nancy J Cox, Rob Sladek, Eric S Lander, Stacey Gabriel, Noël P Burtt, Karen L Mohlke, Thomas Meitinger, Leif Groop, Goncalo Abecasis, Jose C Florez, Laura J Scott, Andrew P Morris, Hyun Min Kang, Michael Boehnke, David Altshuler, and Mark I McCarthy

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Forward-genetics analysis of sleep in randomly mutagenized mice., Hiromasa Funato, Chika Miyoshi, Tomoyuki Fujiyama, Takeshi Kanda, Makito Sato, Zhiqiang Wang, Jing Ma, Shin Nakane, Jun Tomita, Aya Ikkyu, Miyo Kakizaki, Noriko Hotta-Hirashima, Satomi Kanno, Haruna Komiya, Fuyuki Asano, Takato Honda, Staci J Kim, Kanako Harano, Hiroki Muramoto, Toshiya Yonezawa, Seiya Mizuno, Shinichi Miyazaki, Linzi Connor, Vivek Kumar, Ikuo Miura, Tomohiro Suzuki, Atsushi Watanabe, Manabu Abe, Fumihiro Sugiyama, Satoru Takahashi, Kenji Sakimura, Yu Hayashi, Qinghua Liu, Kazuhiko Kume, Shigeharu Wakana, Joseph S Takahashi, and Masashi Yanagisawa

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Tissue fibroblasts: From bystanders to proactive modulators of homeostasis and disease., Milena B Furtado

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The cardiac fibroblast: Origin, identity and role in homeostasis and disease., Milena B Furtado, Mauro W Costa, and Nadia Rosenthal

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View from the heart: cardiac fibroblasts in development, scarring and regeneration., Milena B Furtado, Hieu T Nim, Sarah E Boyd, and Nadia A. Rosenthal

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A novel conditional mouse model for Nkx2-5 reveals transcriptional regulation of cardiac ion channels., Milena B Furtado, Julia C Wilmanns, Anjana Chandran, Mary Tonta, Christine Biben, Michael Eichenlaub, Harold A Coleman, Silke Berger, Romaric Bouveret, Reena Singh, Richard P Harvey, Mirana Ramialison, James T Pearson, Helena C Parkington, Nadia A. Rosenthal, and Mauro W Costa

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Analysis of Expression Pattern and Genetic Deletion of Netrin5 in the Developing Mouse., Andrew M. Garrett, Thomas J. Jucius, Liam P R Sigaud, Fu-Lei Tang, Wen-Cheng Xiong, Susan L. Ackerman, and Robert W. Burgess

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Replacing the PDZ-interacting C-termini of DSCAM and DSCAML1 with epitope tags causes different phenotypic severity in different cell populations., Andrew M. Garrett, Abby Tadenev, Yuna T Hammond, Peter G Fuerst, and Robert W. Burgess

Draft Genome Sequence of Cloacibacterium normanense NRS-1 Isolated from Municipal Wastewater., Nicole R Gay, Elizabeth Fleming, and Julia Oh

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Absence of UCHL 1 function leads to selective motor neuropathy., Barış Genç, Javier H Jara, Megan C Schultz, Marin Manuel, Macdonell J Stanford, Mukesh Gautam, Jodi L Klessner, Gabriella Sekerkova, Daniel B Heller, Gregory A. Cox, Charles J Heckman, Christine J DiDonato, and P Hande Özdinler

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Leukaemia cell of origin identified by chromatin landscape of bulk tumour cells., Joshy George, Asli Uyar, Kira Young, Lauren Kuffler, Kaiden Waldron-Francis, Eladio J Marquez, Duygu Ucar, and Jennifer J. Trowbridge

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Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells., Kristina M Godek, Monica Venere, Quilian Wu, Kevin D Mills, William F Hickey, Jeremy N Rich, and Duane A Compton

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P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer., Hira Lal Goel, Bryan Pursell, Leonard D. Shultz, Dale L Greiner, Rolf A Brekken, Craig W Vander Kooi, and Arthur M Mercurio

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Honoring the work and life of Leroy C. Stevens. A symposium as part of the International Stem Cell Initiative Workshop., Christopher F Graham, Davor Solter, John D Gearhart, Joseph H Nadeau, and Barbara B. Knowles

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Targeting dendritic cells in humanized mice receiving adoptive T cells via monoclonal antibodies fused to Flu epitopes., John P Graham, Pierre Authie, Chun I. Yu, Sandra M Zurawski, Xiao-Hua Li, Florentina Marches, Anne-Laure Flamar, Aditi Acharya, Jacques Banchereau, and A Karolina Palucka

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Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer's disease., Leah C. Graham, Jeffrey M. Harder, Ileana Soto, Wilhelmine N de Vries, Simon W M John, and Gareth R Howell

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Mouse Models of NMNAT1-Leber Congenital Amaurosis (LCA9) Recapitulate Key Features of the Human Disease., Scott H Greenwald, Jeremy R. Charette, Magdalena Staniszewska, Lan Ying Shi, Steve D M Brown, Lisa Stone, Qin Liu, Wanda L. Hicks, Gayle B. Collin, Michael R Bowl, Mark P. Krebs, Patsy M. Nishina, and Eric A Pierce

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TauCstF-64 Mediates Correct mRNA Polyadenylation and Splicing of Activator and Repressor Isoforms of the Cyclic AMP-Responsive Element Modulator (CREM) in Mouse Testis., Petar N Grozdanov, Atia Amatullah, Joel H. Graber, and Clinton C MacDonald

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Oocyte-dependent activation of MTOR in cumulus cells controls the development and survival of cumulus-oocyte complexes., Jing Guo, Lanying Shi, Xuhong Gong, Mengjie Jiang, Yaoxue Yin, Xiaoyun Zhang, Hong Yin, Hui Li, Chihiro Emori, Koji Sugiura, John J. Eppig, and You-Qiang Su

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Genetic Architectures of Quantitative Variation in RNA Editing Pathways., Tongjun Gu, Daniel Mario Gatti, Anuj Srivastava, Elizabeth M Snyder, Narayanan Raghupathy, Petr Simecek, Karen L. Svenson, Ivan Dotu, Jeffrey H Chuang, Mark P Keller, Alan D Attie, Robert E Braun, and Gary A Churchill

The importance of the microbiome in epidemiologic research., Blake M Hanson and George M. Weinstock

Characterization of the bacterial and fungal microbiome in indoor dust and outdoor air samples: a pilot study., Blake M Hanson, Yanjiao Zhou, Eddy J Bautista, Bruce Urch, Mary Speck, Frances Silverman, Michael Muilenberg, Wanda Phipatanakul, George M. Weinstock, Erica Sodergren Weinstock, Diane R Gold, and Joanne E Sordillo

Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells., Suheyla Hasgur, Ken Edwin Aryee, Leonard D. Shultz, Dale L Greiner, and Michael A Brehm

Generation of Genetically Modified Mice Using the CRISPR-Cas9 Genome-Editing System., Jorge Henao-Mejia, Adam Williams, Anthony Rongvaux, Judith Stein, Cynthia Hughes, and Richard A Flavell

De novo frameshift mutation in COUP-TFII (NR2F2) in human congenital diaphragmatic hernia., Frances A High, Pooja Bhayani, Jay M Wilson, Carol J Bult, Patricia K Donahoe, and Mauro Longoni

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Modeling biochemical pathways in the gene ontology., David P. Hill, Peter D'Eustachio, Tanya Z Berardini, Christopher J Mungall, Nikolai Renedo, and Judith A. Blake

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Current state of pediatric sarcoma biology and opportunities for future discovery: A report from the sarcoma translational research workshop., Pooja Hingorani, Katherine Janeway, Brian D Crompton, Cigall Kadoch, Crystal L Mackall, Javed Khan, Jack F Shern, Joshua Schiffman, Lisa Mirabello, Sharon A Savage, Marc Ladanyi, Paul Meltzer, Carol J Bult, Peter C Adamson, Philip J Lupo, Rajen Mody, Steven G DuBois, D Williams Parsons, Chand Khanna, Ching Lau, Douglas S Hawkins, R Lor Randall, Malcolm Smith, Poul H Sorensen, Sharon E Plon, Stephen X Skapek, Stephen Lessnick, Richard Gorlick, and Damon R Reed

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Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis., J Travis Hinson, Anant Chopra, Andre Lowe, Calvin C Sheng, Rajat M Gupta, Rajarajan Kuppusamy, John O'Sullivan, Glenn Rowe, Hiroko Wakimoto, Joshua Gorham, Kehan Zhang, Kiran Musunuru, Robert E Gerszten, Sean M Wu, Christopher S Chen, Jonathan G Seidman, and Christine E Seidman

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Angiogenesis in the skin of SHARPIN-deficient mice with chronic proliferative dermatitis., Harm HogenEsch, Mario Sola, Timothy M Stearns, Kathleen A Silva, Victoria E. Kennedy, and John P Sundberg

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AlgoRun: a Docker-based packaging system for platform-agnostic implemented algorithms., Abdelrahman Hosny, Paola Vera-Licona, Reinhard Laubenbacher, and Thibauld Favre

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Identification of mutations through dominant screening for obesity using C57BL/6 substrains., Mohammad Sarowar Hossain, Fuyuki Asano, Tomoyuki Fujiyama, Chika Miyoshi, Makito Sato, Aya Ikkyu, Satomi Kanno, Noriko Hotta, Miyo Kakizaki, Takato Honda, Staci J Kim, Haruna Komiya, Ikuo Miura, Tomohiro Suzuki, Kimio Kobayashi, Hideki Kaneda, Vivek Kumar, Joseph S Takahashi, Shigeharu Wakana, Hiromasa Funato, and Masashi Yanagisawa

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Lack of Intrinsic GABAergic Connections in the Thalamic Reticular Nucleus of the Mouse., Guoqiang Hou, Alison G Smith, and Zhong-Wei Zhang

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Reducing translation through eIF4G/IFG-1 improves survival under ER stress that depends on heat shock factor HSF-1 in Caenorhabditis elegans., Amber C Howard, Jarod Rollins, Santina Snow, Sarah Castor, and Aric N Rogers

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Ultra-High Resolution 3D Imaging of Whole Cells., Fang Huang, George Sirinakis, Edward S Allgeyer, Lena K Schroeder, Whitney C Duim, Emil B Kromann, Thomy Phan, Felix E Rivera-Molina, Jordan R Myers, Irnov Irnov, Mark Lessard, Yongdeng Zhang, Mary Ann Handel, Christine Jacobs-Wagner, C Patrick Lusk, James E Rothman, Derek Toomre, Martin J Booth, and Joerg Bewersdorf

The development of non-coding RNA ontology., Jingshan Huang, Karen Eilbeck, Barry Smith, Judith A. Blake, Dejing Dou, Weili Huang, Darren A Natale, Alan Ruttenberg, Jun Huan, Michael T Zimmermann, Guoqian Jiang, Yu Lin, Bin Wu, Harrison J Strachan, Nisansa de Silva, Mohan Vamsi Kasukurthi, Vikash Kumar Jha, Yongqun He, Shaojie Zhang, Xiaowei Wang, Zixing Liu, Glen M Borchert, and Ming Tan

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The Non-Coding RNA Ontology (NCRO): a comprehensive resource for the unification of non-coding RNA biology., Jingshan Huang, Karen Eilbeck, Barry Smith, Judith A. Blake, Dejing Dou, Weili Huang, Darren A Natale, Alan Ruttenberg, Jun Huan, Michael T Zimmermann, Guoqian Jiang, Yu Lin, Bin Wu, Harrison J Strachan, Yongqun He, Shaojie Zhang, Xiaowei Wang, Zixing Liu, Glen M Borchert, and Ming Tan

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OmniSearch: a semantic search system based on the Ontology for MIcroRNA Target (OMIT) for microRNA-target gene interaction data., Jingshan Huang, Fernando Gutierrez, Harrison J Strachan, Dejing Dou, Weili Huang, Barry Smith, Judith A. Blake, Karen Eilbeck, Darren A Natale, Yu Lin, Bin Wu, Nisansa de Silva, Xiaowei Wang, Zixing Liu, Glen M Borchert, Ming Tan, and Alan Ruttenberg