Title

Repetitive Behavioral Assessments for Compound Screening in Mouse Models of Autism Spectrum Disorders.

Document Type

Article

Publication Date

2016

JAX Location

Reprint Collection

JAX Source

Methods Mol Biol 2016; 1438:293-310

PMID

27150097

Abstract

Treatments for repetitive behaviors in Autism Spectrum Disorders (ASD) and other neurodevelopmental disorders remain an unmet medical need. Mouse models are highly valuable tools for investigating the underlying pathophysiology, genetics, and neurocircuitry of ASD, and can also be characterized for ASD-related phenotypes including repetitive behaviors and stereotypies. This chapter describes methods that can be employed for the assessment of repetitive behavior phenotypes and the evaluation of the ability of test compounds to attenuate repetitive behaviors in mouse models of ASD. Methods Mol Biol 2016; 1438:293-310

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