Revisiting Cardiac Cellular Composition.
Document Type
Article
Publication Date
2-5-2016
JAX Source
Circ Res 2016 Feb 5; 118(3):400-9
Volume
118
Issue
3
First Page
400
Last Page
409
ISSN
1524-4571
PMID
26635390
Abstract
RATIONALE: Accurate knowledge of the cellular composition of the heart is essential to fully understand the changes that occur during pathogenesis and to devise strategies for tissue engineering and regeneration.
OBJECTIVE: To examine the relative frequency of cardiac endothelial cells, hematopoietic-derived cells, and fibroblasts in the mouse and human heart.
METHODS AND RESULTS: Using a combination of genetic tools and cellular markers, we examined the occurrence of the most prominent cell types in the adult mouse heart. Immunohistochemistry revealed that endothelial cells constitute >60%, hematopoietic-derived cells 5% to 10%, and fibroblasts
CONCLUSIONS: This new perspective on the abundance of different cell types in the heart demonstrates that fibroblasts comprise a relatively minor population. By contrast, endothelial cells constitute the majority of noncardiomyocytes and are likely to play a greater role in physiological function and response to injury than previously appreciated.
Circ Res 2016 Feb 5; 118(3):400-9
Recommended Citation
Pinto A,
Ilinykh A,
Ivey M,
Kuwabara J,
D'Antoni M,
Debuque R,
Chandran A,
Wang L,
Arora K,
Rosenthal N,
Tallquist M.
Revisiting Cardiac Cellular Composition. Circ Res 2016 Feb 5; 118(3):400-9