Title

Splicing-factor alterations in cancers.

Document Type

Article

Publication Date

9-2016

JAX Location

Reprint Collection

JAX Source

RNA 2016 Sep; 22(9):1285-301

PMID

27530828

Abstract

Tumor-associated alterations in RNA splicing result either from mutations in splicing-regulatory elements or changes in components of the splicing machinery. This review summarizes our current understanding of the role of splicing-factor alterations in human cancers. We describe splicing-factor alterations detected in human tumors and the resulting changes in splicing, highlighting cell-type-specific similarities and differences. We review the mechanisms of splicing-factor regulation in normal and cancer cells. Finally, we summarize recent efforts to develop novel cancer therapies, based on targeting either the oncogenic splicing events or their upstream splicing regulators. RNA 2016 Sep; 22(9):1285-301

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