Document Type

Article

Publication Date

2016

JAX Location

Reprint Collection

Abstract

Understanding the interactions between human immune cells and tumors is paramount when devising treatment strategies that prevent tumor evasion of immune cells and improve cytotoxic responses. NSG™* and NSG™-SGM3* mice are a proven host for engraftment of human tumors or establishment of human immunity following hematopoietic stem cell transplantation. Here, we provide evidence that NSG and NSG-SGM3 mice engrafted with hematopoietic stem cells (collectively referred to here as “humanized NSG mice”) can support the growth of allogeneic human tumors. The human tumors respond to standard-of-care chemotherapeutics, targeted therapies, and to immune check-point inhibitors clinically proven to initiate cytotoxic activity towards the tumor. Tumor-bearing, humanized NSG mice (the Onco- Hu™* mouse offered exclusively from The Jackson Laboratory) are a new and valuable preclinical testing platform for immuno-oncology.

Download

Share

COinS