Title

Open chromatin profiling as a novel strategy for identifying cancer cell of origin.

Document Type

Article

Publication Date

9-30-2016

JAX Location

Reprint Collection

JAX Source

Mol Cell Oncol 2016 Sep 30; 3(6):e1236770

PMID

28090579

Grant

CA184851, CA34196, HD007065

Abstract

Tumor cell of origin is an important prognostic measure but is challenging to assess. We recently demonstrated in acute myeloid leukemia (AML) that the chromatin landscape serves as a biomarker of transformed cell of origin. Thus, open chromatin loci offer important prognostic information as well as targets for development of novel therapies in cancer treatment. Mol Cell Oncol 2016 Sep 30; 3(6):e1236770

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