Title

Array-Based Comparative Genomic Hybridization (aCGH).

Document Type

Article

Publication Date

1-1-2017

JAX Location

Reprint Collection

JAX Source

Methods Mol Biol. 2017;1541:167-179.

PMID

27910023

DOI

https://doi.org/10.1007/978-1-4939-6703-2_15

Abstract

Copy number variations (CNVs) in the genomes have been suggested to play important roles in human evolution, genetic diversity, and disease susceptibility. A number of assays have been developed for the detection of CNVs, including fluorescent in situ hybridization (FISH), array-based comparative genomic hybridization (aCGH), PCR-based assays, and next-generation sequencing (NGS). In this chapter, we describe a microarray method that has been used for the detection of genome-wide CNVs, loss of heterozygosity (LOH), and uniparental disomy (UPD) associated with constitutional and neoplastic disorders. Methods Mol Biol. 2017;1541:167-179.

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