Title

Prevalence of sexual dimorphism in mammalian phenotypic traits.

Document Type

Article

Publication Date

6-26-2017

JAX Source

Nat Commun 2017 Jun 26; 8:15475

PMID

28650954

DOI

https://doi.org/10.1038/ncomms15475

Abstract

The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.

Nat Commun 2017 Jun 26; 8:15475.