Title

Properties and Immune Function of Cardiac Fibroblasts.

Document Type

Article

Publication Date

2017

JAX Location

Reprint Collection

JAX Source

Adv Exp Med Biol 2017; 1003:35-70.

PMID

28667553

DOI

https://doi.org/10.1007/978-3-319-57613-8_3

Abstract

This chapter will discuss the role of cardiac fibroblasts as a target of various immunological inputs as well as an immunomodulatory hub of the heart through interaction with immune cell types and chemokine or cytokine signaling. While the purpose of this chapter is to explore the immunomodulatory properties of cardiac fibroblasts, it is important to note that cardiac fibroblasts are not a homogeneous cell type, but have a unique embryological origin and molecular identity. Specific properties of cardiac fibroblasts may influence the way they interact with the heart microenvironment to promote healthy homeostatic function or respond to pathological insults. Therefore, we will briefly discuss these aspects of cardiac fibroblast biology and then focus on their immunomodulatory role in the heart. Adv Exp Med Biol 2017; 1003:35-70.

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