Title

Generating CRISPR mouse models: challenges and solutions.

Document Type

Article

Publication Date

5-12-2017

JAX Source

Science 2017 May 12; 356(6338):649

DOI

https://dx.doi.org/10.1126/science.356.6338.649-b

Abstract

WEBINAR / The discovery of the CRISPR/Cas9 system in bacteria has ignited the world of gene editing. It has been applied to the modification of a growing range of organisms, with none found yet that can resist its powers. In particular, CRISPR technology has revolutionized the process for creating genetically modified mice—the workhorses for in vivo cancer research—allowing for shorter timelines and in many cases, more efficient procedures. In this webinar, our expert panel will discuss the strengths and benefits of CRISPR technology, how it differs from more traditional techniques, and some of the specific challenges it creates. They will share their at-the-bench experiences with viewers, providing practical, actionable information for researchers wanting to apply CRISPR technology to mouse-model generation, particularly for use in cancer research. Science 2017 May 12; 356(6338):649.