Title

Humanized Mouse Models of Clinical Disease.

Document Type

Article

Publication Date

1-24-2017

JAX Source

Annu Rev Pathol 2017; 12:187-215

PMID

27959627

DOI

https://doi.org/10.1146/annurev-pathol-052016-100332

Grant

CA034196, DK104218, OD018259, Maine Cancer Foundation, Sackler Foundation

Abstract

Immunodeficient mice engrafted with functional human cells and tissues, that is, humanized mice, have become increasingly important as small, preclinical animal models for the study of human diseases. Since the description of immunodeficient mice bearing mutations in the IL2 receptor common gamma chain (IL2rg(null)) in the early 2000s, investigators have been able to engraft murine recipients with human hematopoietic stem cells that develop into functional human immune systems. These mice can also be engrafted with human tissues such as islets, liver, skin, and most solid and hematologic cancers. Humanized mice are permitting significant progress in studies of human infectious disease, cancer, regenerative medicine, graft-versus-host disease, allergies, and immunity. Ultimately, use of humanized mice may lead to the implementation of truly personalized medicine in the clinic. This review discusses recent progress in the development and use of humanized mice and highlights their utility for the study of human diseases. Annu Rev Pathol 2017; 12:187-215.

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