Ceftaroline-Resistant, Daptomycin-Tolerant, and Heterogeneous Vancomycin-Intermediate Methicillin-Resistant Staphylococcus aureus Causing Infective Endocarditis.
Document Type
Article
Publication Date
3-2017
JAX Source
Antimicrob Agents Chemother 2017; 61(3):e01235-16
Volume
61
Issue
3
ISSN
1098-6596
PMID
28232309
Abstract
We report a case of infective endocarditis (IE) caused by ceftaroline-resistant, daptomycin-tolerant, and heterogeneous vancomycin-intermediate methicillin-resistant S. aureus (MRSA). Resistance to ceftaroline emerged in the absence of drug exposure, and the E447K substitution in the active site of PBP2a previously associated with ceftaroline resistance was identified. Additionally, we present evidence of patient-to-patient transmission of the strain within the same unit. This case illustrates the difficulties in treating MRSA IE in the setting of a multidrug-resistant phenotype. Antimicrob Agents Chemother 2017; 61(3):e01235-16.
Recommended Citation
Nigo M,
Diaz L,
Carvajal L,
Tran T,
Rios R,
Panesso D,
Garavito J,
Miller W,
Wanger A,
Weinstock GM,
Munita J,
Arias C,
Chambers H.
Ceftaroline-Resistant, Daptomycin-Tolerant, and Heterogeneous Vancomycin-Intermediate Methicillin-Resistant Staphylococcus aureus Causing Infective Endocarditis. Antimicrob Agents Chemother 2017; 61(3):e01235-16