Document Type

Article

Publication Date

1-8-2019

Keywords

JMG

JAX Source

Nucleic Acids 2019 Jan 8; 47(D1):D774-D779

Volume

47

Issue

D1

First Page

774

Last Page

774

ISSN

1362-4962

PMID

30335138

DOI

https://doi.org/10.1093/nar/gky922

Grant

HD062499,HG000330,HD062499

Abstract

The mouse Gene Expression Database (GXD) is an extensive, well-curated community resource freely available at www.informatics.jax.org/expression.shtml. Covering all developmental stages, GXD includes data from RNA in situ hybridization, immunohistochemistry, RT-PCR, northern blot and western blot experiments in wild-type and mutant mice. GXD's gene expression information is integrated with the other data in Mouse Genome Informatics and interconnected with other databases, placing these data in the larger biological and biomedical context. Since the last report, the ability of GXD to provide insights into the molecular mechanisms of development and disease has been greatly enhanced by the addition of new data and by the implementation of new web features. These include: improvements to the Differential Gene Expression Data Search, facilitating searches for genes that have been shown to be exclusively expressed in a specified structure and/or developmental stage; an enhanced anatomy browser that now provides access to expression data and phenotype data for a given anatomical structure; direct access to the wild-type gene expression data for the tissues affected in a specific mutant; and a comparison matrix that juxtaposes tissues where a gene is normally expressed against tissues, where mutations in that gene cause abnormalities.

Comments

This open access article is licensed under a Creative Commons Attribution 4.0 International License

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