Mapping of nucleoside phosphorylase (Np-1) and esterase 10 (Es-10) on mouse chromosome 14.

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Alleles, Animals, Chromosome Mapping, Chromosomes, Crosses, Genetic, Esterases, Female, Genotype, Isoenzymes, Male, Mice, Mice, Inbred Strains, Pentosyltransferases, Purine-Nucleoside Phosphorylase, Recombination, Genetic, Species Specificity


A method for detecting two alleles at Np-1 (nucleoside phosphorylase) and three alleles at Es-10 (esterase 10) from mouse blood by cellulose acetate electrophoresis is described. The allelic constitution at these loci for 44 inbred strains and stocks was determined. The location of Np-1 on chromosome 14 was established by backcross experiments in which alleles at Np-1 and Robertsonian translocations were segregating. Es-10 was shown to be linked to Np-1, and the following genetic map of Chr 14 was constructed: centromere-(8.9 +/- 4.0 cM)-[Np-1, Wc]-(10.2 +/- 1.9 cM)-Es-10-(15.5 +/- 3.7 cM)-s. The homologous human loci, NP and ES-D, are not linked.

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