Maternally transmitted target antigen for unrestricted killing by NZB T lymphocytes.
Document Type
Article
Publication Date
12-1-1980
Keywords
Animals, Antigens, Surface, Cytotoxicity, Immunologic, Female, Genetic Linkage, H-2 Antigens, Immunity, Cellular, Immunologic Memory, Male, Mice, Mice, Inbred BALB C, Mice, Inbred NZB, T-Lymphocytes
Original Citation
J Exp Med 1980 Dec 1; 152(6):1583-95.
Abstract
A new target antigen for unrestricted killing was defined by NZB T lymphocytes which were immunized and restimulated with H-2-identical BALB/c spleen cells. These effector cells killed nearly all target cells tested, irrespective of their H-2 type, but did not kill NZB target cells. The response was shown to have three major components: unrestricted killing specific for Qed-1b, H-2d-restricted killing specific for minor histocompatibility antigens, and unrestricted killing specific for a new antigen, Mta. Mta is present on normal and mitogen-stimulated T and B lymphocytes and on several tumor lines. It was found on cells from 26 mouse strains tested, including two substrains of NZB, representing 9 different H-2 types and 14 different non-H-2 backgrounds. Analysis of the NX8 recombinant inbred lines (derived from Mta-NZB/Icr and Mta+C58/J parents) suggested that Mta is maternally transmitted. This was confirmed by typing of reciprocal F1 hybrids and backcrosses between positive and negative strains: Mta+ females bear Mta+ offspring and Mta- females Mta- offspring, irrespective of the phenotype of the males.