Gene affecting superoxide dismutase activity linked to the histocompatibility complex in H-2 congenic mice.

Document Type


Publication Date



Animals, Biological Evolution, Genes, Genes, Regulator, Genetic Linkage, H-2 Antigens, Liver, Major Histocompatibility Complex, Mice, Superoxide Dismutase

Original Citation

Science 1980 Jan 4; 207(4426):86-7.


The activity of cyanide-sensitive, Cu-Zn superoxide dismutase (SOD) was studied in liver sytosols from H-2 congenic strains of mice. Higher SOD activity was found in livers of mice having H-2b/A.BY, B10, and C3H.SW/haplotypes than in those of H-2a, H-2k and H-2d haplotypes. Segregation studies supported these correlations. In H-2 recombinant strains of mice, the genes influencing the liver SOD activity occur, as ascertained by mapping techniques, at or near the H-2d region of the major histocompatibility complex.

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