Faculty Research 1970 - 1979


Expression of xenotropic murine leukemia viruses as cell-surface gp70 in genetic crosses between strains DBA/2 and C57BL/6.

Document Type


Publication Date



Antigens-Viral: an, Chromosomes, Crosses-Genetic, Female, Genes, Glycoproteins: im, Linkage-(Genetics), Lymphocytes: im, Male, Mice, Mice-Inbred-C57BL, Mice-Inbred-DBA, Mouse-Leukemia-Viruses: gd, im, Viral-Proteins: im

First Page


Last Page


JAX Source

J-Exp-Med. 1979 May 1; 149(5):1183-96.


Flow microfluorometry was used to assess levels of xenotropic murine leukemia virus envelope-related cell-surface antigens (XenCSA) expressed on lymphocytes of mice derived from crosses between C57BL/6 (B6) and DBA/2 (D2); 24 recombinant inbred strains (BXD RIs) and 62 backcross mice were studied. The results suggest that XenCSA expression is affected by more than one gene but that the predominant influence is exerted by a single semidominant gene apparently located on chromosome 4 at or in close proximity to the Fv-1 locus. Studies of spontaneous virus production in B6D2F1 X D2 mice suggest that this locus may also affect production by spleen cells of xenotropic MuLV registering in a fluorescent antibody assay of mink lung cells.

Please contact the Joan Staats Library for information regarding this document.