Evidence for a particle-associated RNA-directed DNA polymerase in rabbit placental and uterine tissues.

Authors

H G. Bedigian
R R. Fox
H Meier

Document Type

Article

Publication Date

1976

Keywords

C-Type-Viruses: en, DNA-Polymerases: me, Female, Gestational-Age, Oligodeoxyribonucleotides: me, Placenta: en, mi, Poly-A: me, Poly-T: me, Polynucleotides: me, Pregnancy, Rabbits, Reverse-Transcriptase: ip, RNA-Viral: me, SUPPORT-U-S-GOVT-P-H-S, Uterus: en, mi

First Page

4687

Last Page

4692

JAX Location

41,814

JAX Source

Cancer-Res. 1976 Dec; 36(12):4687-92.

Abstract

A RNA-directed DNA polymerase associated with particles that band at a density characteristic of type C RNA viruses was found in normal rabbit placental and uterine tissues taken during the early stages of gestation. That the rabbit RNA-directed DNA polymerase is distinct from the known cellular DNA polymerases and similar to the RNA-directed DNA polymerase of mammalian type C RNA viruses is shown by column chromatographic characteristics, template primer preferences, molecular weight determination, and an absolute requirement for the divalent cations.

Recommended Citation

Bedigian HG, Fox RR, Meier H. Evidence for a particle-associated RNA-directed DNA polymerase in rabbit placental and uterine tissues. Cancer-Res. 1976 Dec; 36(12):4687-92.