Faculty Research 1970 - 1979

Immunogenetic analysis of H-2 mutations. IV. Mapping of and immune reactions to the H-2fa mutation.

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Chromosome-Mapping, Female, Graft-Rejection, Graft-Vs-Host-Reaction, Histocompatibility, Immunity-Cellular, Leukocyte-Culture-Test-Mixed, Lymphocytes: im, Male, Mice, Mice-Inbred-Strains, Mutation, Skin: tr, SUPPORT-U-S-GOVT-P-H-S, Transplantation-Homologous

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JAX Source

Scand-J-Immunol. 1976; 5(5):521-8.


H-2fa is a spontaneous mutation that occurred in an (A.CA X A)F1 female mouse and was later transferred on an A-strain background [congenic line A.CA (M506) or M506]. Skin grafts exchanged between M506 and A.CA strains are rejected within 4 weeks after grafting. Significant reaction is observed when these two strains are used as responders and stimulators in mixed lymphocyte culture or in a splenomegaly graft-versus-host assay. The mutant antigen induces strong cell-mediated lymphocytotoxicity. The mutation maps in the K end of the H-2 complex. The capacity of mutant antigens to induce relatively strong lymphocyte proliferation is explained by hypothesizing that the T-cell receptors reacting with K- or D-region products can more easily recognize subtle than drastic alloantigenic differences.

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