Faculty Research 1970 - 1979


Myodystrophy, a new myopathy on chromosome 8 of the mouse.

Document Type


Publication Date



Chromosome-Mapping, Crosses-Genetic, Female, Genes, Genes-Recessive, Linkage-(Genetics), Male, Mice, Muscular-Diseases: fg, ve, Mutation, Phenotype, Pigmentation, Rodent-Diseases: fg, SUPPORT-U-S-GOVT-NON-P-H-S

JAX Source

J-Hered. 1976 May-Jun; 67(3):135-8.


A new recessive mutation, myd, causing a diffuse and progressive myopathy in the mouse is described. Histopathological comparisons with normal littermates showed widely distributed focal lesions in all skeletal muscles of myd/myd. Body and organ weights of affected mice were considerably less than those of normal littermates and the mean lifespan of myodystrophic mice that survived weaning was 17 weeks with a range of 5 to 39 weeks. Myodystrophy is located on chromosome 8; it is linked to Os with about 6 percent and to Eso with about 37 percent recombination.

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