Faculty Research 1970 - 1979
Genetic control of glucokinase activity in mice.
Document Type
Article
Publication Date
1977
Keywords
Comparative-Study, Crosses-Genetic, Diabetes-Mellitus: en, ci, Fasting, Female, Glucokinase: me, Insulin, Liver: de, en, Male, Mice, Mice-Inbred-Strains, Species-Specificity, Streptozotocin, SUPPORT-U-S-GOVT-P-H-S, Variation-(Genetics)
First Page
297
Last Page
305
JAX Location
42,044
JAX Source
Biochem-Genet. 1977 Apr; 15(3-4):297-305.
Abstract
Inbred strains of mice were surveyed for liver glucokinase activity. Mice of all strains studied could be distributed into three groups with high, intermediate, and low levels of enzyme activity. Genetic analysis using crosses and backcrosses with prototype high (C3H/HeJ) and low (RF/J) strains revealed that glucokinase activity was controlled by a single gene. The name "glucokinase: and gene symbol Gk are suggested for this gene. The Gka allele designates the strain with high glucokinase activity, while Gkb represents the allele in the strain with the low enzyme activity. The interaction of fasting and diabetes on the activity of glucokinase in these two strains is described.
Recommended Citation
Coleman DL.
Genetic control of glucokinase activity in mice. Biochem-Genet. 1977 Apr; 15(3-4):297-305.