Faculty Research 1970 - 1979

Pathological changes during aging in barrier-reared Fischer 344 male rats.

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Aging, Alpha-Globulins: an, Animal, Blood-Proteins: an, Cardiovascular-System: pa, Cholesterol, Germ-Free-Life, Kidney: pa, Kidney-Diseases: pa, Leukemia-Monocytic: pa, Leydig-Cell-Tumor: pa, Male, Pituitary-Neoplasms: pa, Rats, Rats-Inbred-F344: ph, Rats-Inbred-Strains: ph, Respiratory-System: pa, Serum-Albumin: an, Specific-Pathogen-Free, Spleen: pa, SUPPORT-U-S-GOVT-P-H-S, Testicular-Neoplasms: pa, Testis: pa

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J-Gerontol. 1977 May; 32(3):258-78.


Pathology, microbiology, and selected serum chemistries were evaluated in 144 male Fischer rats from 4 to 33 mo of age. The rats were reared and maintained under barrier conditions, which successfully excluded the introduction of major infectious disease agents throughout the entire study, including Mycoplasma pulmonis. A wide variety of pathology was found and tabulated, and many lesions were found to increase in severity and incidence with age. There was a high correlation of renal disease severity with increasing age, while alpha-1 globulin and cholesterol increased.

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