Induction of type C RNA virus from cultured rabbit lymphosarcoma cells.

Authors

H G. Bedigian
R R. Fox
H Meier

Document Type

Article

Publication Date

1978

Keywords

Antigenic-Determinants, C-Type-Viruses: de, en, gd, Cell-Line, Idoxuridine, Lymphoma-Non-Hodgkin's, Rabbits, Reverse-Transcriptase: im, me, RNA-Viruses, SUPPORT-U-S-GOVT-P-H-S, Virus-Replication: de

First Page

313

Last Page

319

JAX Location

42,698

JAX Source

J-Virol. 1978 Aug; 27(2):313-9.

Abstract

Type C RNA virus(es) was readily released from primary lymphosarcoma cell cultures of WH/J rabbits after induction with halogenated pyrimidines. The virus contained an RNA-directed DNA polymerase and the p30 structural protein. The rabbit virus RNA-directed DNA polymerase and p30 protein shared antigenic homologies with other mammalian type C oncornaviruses but appear to also possess unique antigenic determinants. Normal rabbit liver contained DNA homologous to a 3H-labeled complementary DNA transcript of the rabbit viral genome, indicating that type C viral genetic information is present in at least the WH/J strain of rabbits.

Recommended Citation

Bedigian HG, Fox RR, Meier H. Induction of type C RNA virus from cultured rabbit lymphosarcoma cells. J-Virol. 1978 Aug; 27(2):313-9.