Faculty Research 1970 - 1979
The genetic mapping of a defective LPS response gene in C3H/HeJ mice.
Document Type
Article
Publication Date
1978
Keywords
Chromosome-Mapping, English-Abstract, Escherichia-Coli: im, Genes-Immune-Response, Lipopolysaccharides, Lymphocyte-Transformation, Mice, Mice-Inbred-C3H, Mice-Inbred-Strains, Polysaccharides-Bacterial, Proteinuria: fg, Syndactylia: fg
First Page
422
Last Page
424
JAX Source
J-Immunol. 1978 Feb; 120(2):422-4.
Abstract
The expression of a defective LPS response gene Lps and the major urinary protein (Mup-1) are concordantly inherited in backcross (C3H/HeJ x C57BL/6J)F1 x C3H/HeJ mice, indicating genetic linkage of these loci. Mup-1 is known to be linked to the brown coat color locus on chromosome 4 in mice; thus Lps can now be assigned to chromosome 4. A value of 0.06 +/- 0.02 has been estimated for the recombination frequency between Mup-1 and Lps. We have used the polysyndactyly (Ps) mutation further to localize Lps on chromosome 4. Lps is located between the Mup-1 and Ps loci.
Recommended Citation
Watson J,
Kelly K,
Largen M,
Taylor BA.
The genetic mapping of a defective LPS response gene in C3H/HeJ mice. J-Immunol. 1978 Feb; 120(2):422-4.