Faculty Research 1970 - 1979
Title
Development of velvet coat (Ve/Ve), another early lethal mutation in the house mouse.
Document Type
Article
Publication Date
1979
Keywords
Blastocyst, Embryo-Resorption, Female, Genes-Lethal, Homozygote, Mesoderm, Mice: ge, Pregnancy, SUPPORT-U-S-GOVT-P-H-S, Time-Factors
First Page
237
Last Page
242
JAX Source
Anat-Embryol-(Berl). 1979 Oct; 157(2):237-42.
Abstract
A new semidominant mutation in the house mouse, velvet coat (Ve), is described. Ve homozygotes, recognizable on day 5 of gestation by their deficiency of ectodermal cells, never produce mesoderm and are resorbed by days 9-10. Primary Ve action may occur during the formation of the blastocyst or during determination and differentiation of the inner cell mass, or both. Accordingly, Ve/Ve embryos may provide a useful model for investigating primary gene action during blastocyst formation and subsequent differentiation.
Recommended Citation
Granholm NH,
Stevens LC,
Theiler K.
Development of velvet coat (Ve/Ve), another early lethal mutation in the house mouse. Anat-Embryol-(Berl). 1979 Oct; 157(2):237-42.