Faculty Research 1980 - 1989

Title

Deleterious effects of irradiation and bone marrow transplantation therapy in the genetically anemic an/an mouse.

Document Type

Article

Publication Date

1989

Keywords

Animal, Bone-Marrow: re, pa, tr, Erythrocytes: re, pa, tr, Leukocytes: re, pa, tr, Longevity: re, Mice, Mice-Inbred-C57BL, Mice-Mutant-Strains, Radiation-Chimera, SUPPORT-U-S-GOVT-P-H-S

JAX Location

1803

JAX Source

Blood 1989 Apr; 73(5):1373-9.

Grant

CA43271, DK27726, S07RR05545

Abstract

The efficacy and outcome of bone marrow transplantation therapy following lethal irradiation were examined in syngeneic mice that had a hereditary macrocytic anemia (an/an) or were genotypically normal (+/+). Successful RBC and WBC replacement, based on blood cell parameters and donor genetic markers, were observed in all combinations of transplant therapy. Nevertheless, the an/an mice died prematurely several months after treatment, whether they received +/+ or an/an marrow cells. In contrast, the +/+ recipients of either +/+ or an/an marrow cells survived for at least 1 year after transplantation. Premature death of the an/an mice was associated with lymphopenia, anemia, kidney lesions, and severe pathogen-free pneumonitis. On the basis of our results, we hypothesize that the premature deaths of an/an mice are caused by a kind of chronic irradiation damage to which an/an mice are especially susceptible.

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