Faculty Research 1980 - 1989


A negative regulatory element with properties similar to those of enhancers is contained within an Alu sequence.

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Publication Date



Cercopithecus-aethiops: ge, Enhancer-Elements-(Genetics), Genes-Regulator, Genetic-Vectors, Globin: ge, Human, Promoter-Regions-(Genetics), Repetitive-Sequences-Nucleic-Acid, RNA-Probes, SUPPORT-NON-U-S-GOVT, SV40-Virus: ge, Transcription-Genetic

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JAX Source

Mol Cell Biol 1989 Feb; 9(2):355-64.


A negative regulatory element has been found within a member of the African green monkey Alu family of interspersed repeated sequences. This "reducer: element decreased transcription in both directions from a cellular simian virus 40-like bidirectional promoter independently of both orientation and position. The reducer was not promoter specific since it also decreased expression from the simian virus 40 early and human beta-globin promoters. In addition, the reducer decreased transcription from a polymerase III promoter. The reducer was contained in 38 base pairs of an Alu family member and interacted specifically with a monkey cell nuclear protein.

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