Faculty Research 1980 - 1989

Title

gamma-Glutamyl cyclotransferase: a new genetic polymorphism in the mouse (Mus musculus) linked to Lyt-2.

Document Type

Article

Publication Date

1981

Keywords

Antigens-Ly: ge, Chromosome-Mapping, Crosses-Genetic, Female, Gamma-Glutamyltransferase: ge, Genes-Structural, Linkage-(Genetics), Male, Mice, Mice-Inbred-C3H: ge, Mice-Inbred-C57BL: ge, Polymorphism-(Genetics), SUPPORT-U-S-GOVT-P-H-S

JAX Source

Genetics. 1981 Sep; 99(1):109-16.

Grant

GM18684, GM07419

Abstract

Electrophoretically variant forms of gamma-glutamyl cyclotransferase have been identified in red cells of inbred mouse strains. Each inbred strain exhibited a major band of activity and a minor band that migrated more anodally. The polymorphism affects the migration of both the major and minor bands in a similar way. F1 hybrids between strains with fast forms (A/J) and strains with the slow forms (C57BL/6J) exhibited a four-banded pattern consistent with co-dominant inheritance. The patterns observed in backcross and F2 mice were consistent with the segregation of a pair of autosomal co-dominant alleles. Recombinant inbred strains and a congenic strain were used to show that the locus controlling gamma-glutamyl cyclotransferase (Ggc) is linked to Lyt-2, a lymphocyte alloantigen locus on chromosome 6, with an estimated map distance of 5.0 +/- 2.5 centimorgans.

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