Faculty Research 1980 - 1989

Title

Murine "viable motheaten: mutation reveals a gene critical to the development of both B and T lymphocytes.

Document Type

Article

Publication Date

1989

Keywords

Antibodies-Monoclonal, B-Lymphocytes: im, Bone-Marrow: tr, Enzyme-Linked-Immunosorbent-Assay, Flow-Cytometry, Genes, IgM: an, ge, Immunoglobulin-Allotypes: ge, Mice, Mice-Inbred-Strains, Mice-Mutant-Strains: im, Mutation, SUPPORT-U-S-GOVT-P-H-S, T-Lymphocytes: im

JAX Location

1851

Grant

AI20232, AI25765, CA35845

Abstract

In lethally irradiated normal mice reconstituted with both normal and autoimmune mutant viable motheaten (mev) bone marrow, the mev-derived B and T cells display aberrant behavior, while those derived from the normal bone marrow develop and function normally. The observed developmental abnormalities of mev B and T lymphocytes are therefore intrinsic to these cell types, rather than being determined by defective influences from the cells' environment. These data bring into question the in vivo significance of reported intercellular regulatory defects in motheaten (me) and mev mice and suggest that these mutations affect a gene whose product acts cell autonomously in the development of several hematopoietic cell lineages including B and T lymphocytes.

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