Faculty Research 1980 - 1989
Murine "viable motheaten: mutation reveals a gene critical to the development of both B and T lymphocytes.
Document Type
Article
Publication Date
1989
Keywords
Antibodies-Monoclonal, B-Lymphocytes: im, Bone-Marrow: tr, Enzyme-Linked-Immunosorbent-Assay, Flow-Cytometry, Genes, IgM: an, ge, Immunoglobulin-Allotypes: ge, Mice, Mice-Inbred-Strains, Mice-Mutant-Strains: im, Mutation, SUPPORT-U-S-GOVT-P-H-S, T-Lymphocytes: im
First Page
6279
Last Page
6282
JAX Location
1851
Grant
AI20232, AI25765, CA35845
Abstract
In lethally irradiated normal mice reconstituted with both normal and autoimmune mutant viable motheaten (mev) bone marrow, the mev-derived B and T cells display aberrant behavior, while those derived from the normal bone marrow develop and function normally. The observed developmental abnormalities of mev B and T lymphocytes are therefore intrinsic to these cell types, rather than being determined by defective influences from the cells' environment. These data bring into question the in vivo significance of reported intercellular regulatory defects in motheaten (me) and mev mice and suggest that these mutations affect a gene whose product acts cell autonomously in the development of several hematopoietic cell lineages including B and T lymphocytes.
Recommended Citation
Sidman CL,
Marshall JD,
Allen RD.
Murine "viable motheaten: mutation reveals a gene critical to the development of both B and T lymphocytes. . 1989; ():6279