Faculty Research 1980 - 1989

Title

The cardiac actin locus (Actc-1) is not on mouse chromosome 17 but is linked to beta 2-microglobulin on chromosome 2.

Document Type

Article

Publication Date

1989

Keywords

Animal, Beta-2-Microglobulin: ge, Chromosome-Mapping, Chromosomes-Human-Pair-15, Comparative-Study, Human, Linkage-(Genetics), Mice, Mice-Inbred-Strains, Restriction-Fragment-Length-Polymorphisms, Species-Specificity, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S

JAX Location

1814

Grant

GM32461, GM39414

Abstract

A restriction fragment variant and recombinant inbred strains were used to show that the cardiac actin locus (Actc-1) is closely linked to beta 2-microglobulin (B2m) and several other loci on chromosome 2 of the mouse. Close linkage of Actc-1 and B2m in both man and mouse provides another example of a chromosomal segment that has been conserved since the divergence of the lineages leading to these two species.

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