Linkage of the mouse LDL receptor gene on chromosome 9.
Blotting-Southern, Chromosomes, Crosses-Genetic, Genetic-Markers, Genotype, Linkage-(Genetics), Mice, Mice-Inbred-Strains, Nucleotide-Mapping, Receptors-LDL: ge, Recombination-Genetic, Restriction-Fragment-Length-Polymorphisms, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S
PO1HL30568, CA33093, GM18684
We identified restriction fragment length variants of the mouse low-density lipoprotein receptor gene and used these to map the gene, designated Ldlr, to the proximal region of chromosome 9. An interspecific backcross between strains MEV and CAST/Ei yielded the following gene order and distances in centimorgans: Ldlr-18.8 +/- 5.6-Apoa-4-7.3 +/- 3.5-Mpi-1-10.2 +/- 3.9-Emv-3 or dilute. Analysis of recombinant inbred strains also indicated that Ldlr is tightly linked to a previously unmapped retroviral marker, Xmmv-67.
Frank, S L.; Taylor, B A.; and Lusis, A J., " Linkage of the mouse LDL receptor gene on chromosome 9." (1989). Faculty Research 1980 - 1989. 1135.