Faculty Research 1980 - 1989

Title

Linkage of the mouse LDL receptor gene on chromosome 9.

Document Type

Article

Publication Date

1989

Keywords

Blotting-Southern, Chromosomes, Crosses-Genetic, Genetic-Markers, Genotype, Linkage-(Genetics), Mice, Mice-Inbred-Strains, Nucleotide-Mapping, Receptors-LDL: ge, Recombination-Genetic, Restriction-Fragment-Length-Polymorphisms, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

Grant

PO1HL30568, CA33093, GM18684

Abstract

We identified restriction fragment length variants of the mouse low-density lipoprotein receptor gene and used these to map the gene, designated Ldlr, to the proximal region of chromosome 9. An interspecific backcross between strains MEV and CAST/Ei yielded the following gene order and distances in centimorgans: Ldlr-18.8 +/- 5.6-Apoa-4-7.3 +/- 3.5-Mpi-1-10.2 +/- 3.9-Emv-3 or dilute. Analysis of recombinant inbred strains also indicated that Ldlr is tightly linked to a previously unmapped retroviral marker, Xmmv-67.

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