Faculty Research 1980 - 1989
A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11.
Animal, Blotting-Southern, Chromosomes, Crosses-Genetic, Female, Genes-Homeo-Box, Genes-Reiterated, Hamsters, Hybrid-Cells, Keratin: ge, Linkage-(Genetics), Male, Mice, Mutation, Rats, Recombination-Genetic, SUPPORT-U-S-GOVT-P-H-S
GM32461, GM39414, AM37108, +
Type I and type II keratins are major constituents of intermediate filaments that play a fundamental role in the cytoskeletal network. By using both somatic cell hybrids and conventional and interspecific linkage crosses, several genes encoding type I keratins, including the epidermal keratin K10, were shown to be closely linked to the homeobox-2 complex and the rex locus on mouse chromosome 11. The absence of crossovers between type I keratin-encoding genes and rex (N = 239), a locus affecting hair development, raises the possibility that mutations at rex and neighboring loci affecting skin and hair development involve type I keratin genes.
Nadeau, J H.; Berger, F G.; Cox, D R.; Crosby, J L.; Davisson, M T.; Ferrara, D; Fuchs, E; Hart, C; Hunihan, L; and Lalley, P A., "A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11." (1989). Faculty Research 1980 - 1989. 1136.