Faculty Research 1980 - 1989

Title

A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11.

Document Type

Article

Publication Date

1989

Keywords

Animal, Blotting-Southern, Chromosomes, Crosses-Genetic, Female, Genes-Homeo-Box, Genes-Reiterated, Hamsters, Hybrid-Cells, Keratin: ge, Linkage-(Genetics), Male, Mice, Mutation, Rats, Recombination-Genetic, SUPPORT-U-S-GOVT-P-H-S

JAX Location

1892

Grant

GM32461, GM39414, AM37108, +

Abstract

Type I and type II keratins are major constituents of intermediate filaments that play a fundamental role in the cytoskeletal network. By using both somatic cell hybrids and conventional and interspecific linkage crosses, several genes encoding type I keratins, including the epidermal keratin K10, were shown to be closely linked to the homeobox-2 complex and the rex locus on mouse chromosome 11. The absence of crossovers between type I keratin-encoding genes and rex (N = 239), a locus affecting hair development, raises the possibility that mutations at rex and neighboring loci affecting skin and hair development involve type I keratin genes.

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