Faculty Research 1980 - 1989

Title

Ath-2, a second gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice.

Document Type

Article

Publication Date

1989

Keywords

Animal, Apolipoproteins-A: ge, Arteriosclerosis: ge, Atherosclerosis: ge, Disease-Susceptibility, Female, Genes, Heterozygote, Linkage-(Genetics), Lipoproteins-HDL: ge, Male, Mice, Mice-Inbred-C57BL, Mice-Inbred-Strains, Phenotype, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Genetics 1989 May;122(1):163-8

Grant

HL32087, HL28481, RR05467

Abstract

Strain C57BL/6J and A/J differ at two genes determining atherosclerosis susceptibility. The first gene, Ath-1, was described earlier and this report characterizes Ath-2. The alleles at Ath-2 are r for resistance and s for susceptibility to atherosclerosis. The resistant phenotype in female mice is characterized by high plasma high density lipoprotein-cholesterol levels (74 mg/dl +/- SEM 2) and very few lesions/mouse after 14 weeks of consumption of an atherogenic diet (0.1 +/- SEM 0.1 in a predetermined region of the aorta). The susceptible phenotype in female mice is characterized by low levels of high density lipoprotein-cholesterol (35 mg/dl +/- SEM 1) and 1.2 lesions/mouse +/- SEM 0.2 in the same region of the aorta. In Ath-2 heterozygotes, resistance is dominant to susceptibility. Recombinant inbred strains derived from C57BL/6 and A were characterized for Apoa 1, Apoa 2 and susceptibility to atherosclerosis. Ath-1 and Ath-2 interact with each other so that resistant alleles at either locus confer a resistant phenotype to the animal. The map position of Ath-2 is not known, but Ath-2 does not map near genes determining the apolipoproteins for A-I, A-II, or E.

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