Faculty Research 1980 - 1989

Title

Screening for mouse retinal degenerations. II. Molossinus MOLC and MOLD strains.

Document Type

Article

Publication Date

1989

Keywords

Dark-Adaptation, Disease-Models-Animal, Electroretinography, Fundus-Oculi, Mice, Mice-Inbred-Strains: ge, Ophthalmoscopy, Pedigree, Photography, Retinal-Degeneration: ge, di, pa, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Doc Ophthalmol 1989 Mar;71(3):241-52

Grant

1R01Ey0775801

Abstract

Using screening techniques of indirect ophthalmoscopy, electroretinography, and histology, we found inbred strains of Mus musculus molossinus to have a variable onset of retinal degeneration, which may present with early loss of outer segments and photoreceptor nuclei. The early affected mice have constricted vessels, optic atrophy, and markedly abnormal electroretinograms. An intermediate form of retinal degeneration was identified with slight arterial narrowing on ophthalmoscopy and electroretinogram amplitudes approximately 50% of normal. From this preliminary study the hereditary pattern is unclear. The mice with early onset of retinal degeneration share features seen in rd mice, but in a number of the molossinus the degeneration is slower with only a partial loss on electroretinogram amplitude.

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