Faculty Research 1980 - 1989

Title

Lethal effect of cis- but not trans-22-dehydrocholesterol on mouse fibroblast cells.

Document Type

Article

Publication Date

1981

Keywords

Cell-Survival: de, Cells-Cultured, Cholestadienols, Cholesterol, Dehydrocholesterols, Fibroblasts: cy, me, Hydroxycholesterols, Rubidium: me, Stereoisomers, SUPPORT-U-S-GOVT-NON-P-H-S, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Lipids. 1981 Dec; 16(12):943-5.

Grant

CA02758

Abstract

cis- and trans-22-dehydrocholesterol were incorporated into the culture medium for mouse fibroblasts cells. Although neither isomer had an effect on sterol biosynthesis, the cis isomer inhibited cell growth and viability and increased Rb+ efflux from the cells. The trans isomer had no effect on growth and could replace exogenous cholesterol for growth of cells for which sterol biosynthesis was blocked by 25-hydroxycholesterol.

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