Faculty Research 1980 - 1989

Title

SV40 T antigen acts as a minor histocompatibility antigen of SV40 T antigen tolerant transgenic mice.

Document Type

Article

Publication Date

1989

Keywords

Antigens-Polyomavirus-Transforming: ge, im, Cell-Line-Transformed, Cytotoxicity-Immunologic, Immune-Tolerance, Lymphocyte-Transformation, Mice, Mice-Inbred-C57BL, Mice-Transgenic: im, Minor-Histocompatibility-Loci, Spleen, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S, T-Lymphocytes-Cytotoxic: im

JAX Source

Immunogenetics 1989;29(6):366-70

Grant

CA10815, CA21124

Abstract

The ability of normal mice to mount an SV40 T antigen-specific cytolytic T lymphocytes response when immunized in vivo with splenocytes from the SV40 T antigen transgenic 427-line mice and restimulated in vitro with SV40-transformed fibroblasts, or when immunized with SV40 and restimulated with 427-line splenocytes, was analyzed. Both immunization schemes resulted in an SV40 T antigen-specific immune response, indicating the presence of SV40 T antigen-positive cells in the spleens of these transgenic mice. Normal mice engrafted with skin from 427 donors showed no rejection of the graft. Thus, SV40 T antigen in transgenic 427-line mice is expressed on an undefined cell type in the spleen and acts as a tissue-specific minor histocompatibility antigen.

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