Faculty Research 1980 - 1989

Title

Linkage of Pgm-3 in the house mouse and homologies of three phosphoglucomutase loci in mouse and man.

Document Type

Article

Publication Date

1981

Keywords

Animal, Comparative-Study, Heterozygote, Human, Isoenzymes: ge, Linkage-(Genetics), Major-Histocompatibility-Complex, Mice, Mice-Inbred-Strains, Phenotype, Phosphoglucomutase: ge, Species-Specificity, SUPPORT-NON-U-S-GOVT, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Biochem-Genet. 1981 Jun; 19(5-6):465-74.

Grant

GM18684, A10553102

Abstract

The discovery of a third phosphoglucomutase locus (Pgm-3) in the house mouse is reported. Three alleles are recognized on the basis of differences in electrophoretic mobility and enzymatic activity. Pgm-3A (fast mobility and high activity) is present in inbred strain C57BL/10J and 24 other strains; Pgm-3b (slow mobility and high activity) is present in LP/Pas and six other strains; and Pgm-3c (no detectable activity in any tissue tested) is present in strain DBA/2J and 14 other strains. Seventy-four recombinant inbred strains derived from progenitors that differed at Pgm-3 were used to study genic linkage. Pgm-3 is on chromosome 9 and is linked to Sep-1, d, Mod-1, and Ltw-3. Gene order and recombination frequencies are estimated as d 3.8 +/- 1.8%. Pgm-3 2.3 +/- 1.2% Mod-1. Substrate specificities and cofactor requirements show that mouse Pgm-1 is homologous with human Pgm-2, mouse Pgm-2 with human Pgm-1, and mouse Pgm-3 with human Pgm-3.

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