Faculty Research 1980 - 1989

Title

Inheritance of delta 9-tetrahydrocannabinol seizure susceptibility in rabbits.

Document Type

Article

Publication Date

1981

Keywords

Behavior-Animal: de, Rabbits, Seizures: fg, ci, SUPPORT-U-S-GOVT-P-H-S, Tetrahydrocannabinol

JAX Source

J-Hered. 1981 May-Jun; 72(3):215-6.

Grant

DA01448, RR00251

Abstract

Delta 9-Tetrahydrocannabinol (THC), the major psychoactive ingredient of marijuana, causes nonfatal convulsions in rabbits of a closed colony of New Zealand White rabbits (Uaz: NZW). The convulsive phenotype appears to be associated with homozygous expression of a single autosomal recessive gene with full penetrance. We propose the symbol thc for the gene responsible for this condition. We also propose that this closed colony of New Zealand White rabbits at the University of Arizona, in which the thc gene is segragating, be designated Uaz:NZW-thc.

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