Faculty Research 1980 - 1989

Title

Genetic and physiological aspects of cholesterol accumulation in hyperresponding and hyporesponding rabbits.

Document Type

Article

Publication Date

1981

Keywords

Animal, Cholesterol: an, Comparative-Study, Esterases: ge, Female, Genotype, Liver: an, Male, Rabbits: ge, me, SUPPORT-U-S-GOVT-P-H-S

JAX Source

Lab-Anim. 1981 Jan; 15(1):61-7.

Grant

RR00251

Abstract

After a 5 week period of feeding a cholesterol-rich diet to rabbits, hyperresponders with high plasma cholesterol levels and hyporesponders with low plasma cholesterol levels could be distinguished from normal responders. The response was found to be correlated with the esterase genotype at the Est-2 locus. The increase in total body cholesterol was higher in hyper-than in hyporesponders. In both groups most of the accumulated dietary cholesterol was found in plasma and liver. Adrenal weight and plasma corticosterone levels were more increased in hyper- than in hyporesponders. The cholesterol-rich diet resulted in an augmentation of liver lipase and lipoprotein lipase activities. These lipolytic activities were more increased in hyper- than in the hyporesponders.

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